• Peter Gunning

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introduction and Historical Perspective

    1. Peter Gunning
      Pages 1-5
  3. Genes and Their Expression

    1. Bernadette Vrhovski, Nadine Thézé, Pierre Thiébaud
      Pages 6-26
    2. Clare Gooding, Christopher W. J. Smith
      Pages 27-42
    3. Galina Schevzov, Geraldine O’Neill
      Pages 43-59
  4. Protein Structure

    1. Sarah E. Hitchcock-DeGregori
      Pages 60-72
    2. Mario Gimona
      Pages 73-84
  5. Role in Muscle Function

    1. Larry S. Tobacman
      Pages 85-94
    2. William Lehman, Roger Craig
      Pages 95-109
    3. Steve Marston, M. El-Mezgueldi
      Pages 110-123
  6. Tropomyosin in Human Disease

    1. David M. Helfman, Patrick Flynn, Protiti Khan, Ali Saeed
      Pages 124-131
    2. David F. Wieczorek, Ganapathy Jagatheesan, Sudarsan Rajan
      Pages 132-142
    3. Anthony J. Kee, Edna C. Hardeman
      Pages 143-157
    4. Kiron M. Das, Manisha Bajpai
      Pages 158-167
  7. Tropomyosin Directed Regulation of the Cytoskeleton

    1. David Pruyne
      Pages 168-186
    2. Claire Martin, Peter Gunning
      Pages 187-200
    3. Jim Jung-Ching Lin, Robbin D. Eppinga, Kerri S. Warren, Keith R. McCrae
      Pages 201-222
  8. Mechanisms of Tropomyosin Function

    1. Uno Lindberg, Clarence E. Schutt, Robert D. Goldman, Maria Nyåkern-Meazza, Louise Hillberg, Li-Sophie Zhao Rathje et al.
      Pages 223-231
    2. Thomas B. Kuhn, James R. Bamburg
      Pages 232-249
    3. E. Michael Ostap
      Pages 273-282
  9. Conclusion

  10. Back Matter
    Pages 299-304

About this book


A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.


cancer cell differentiation dynamics gene expression protein protein structure proteins regulation

Editors and affiliations

  • Peter Gunning
    • 1
  1. 1.Oncology Research Unit, Department of Pharmacology School of Medical SciencesUniversity of New South WalesSydneyAustralia

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