© 2009

Mitochondria and Cancer

  • Editors
  • Leslie Costello
  • Keshav Singh


  • Aims to provide a comprehensive analysis of the role mitochondria play in carcinogenesis

  • Will also provide up to date mitochondrial therapeutic approaches for treatment of cancer


Table of contents

  1. Front Matter
    Pages i-xii
  2. Kjerstin M. Owens, J. S. Modica-Napolitano, Keshav K. Singh
    Pages 1-21
  3. Michael Ristow, Tim J. Schulz
    Pages 23-38
  4. Koen Brusselmans, Johannes V. Swinnen
    Pages 39-59
  5. Renty B. Franklin, Leslie C. Costello
    Pages 61-78
  6. Roberto Scatena, Patrizia Bottoni, Bruno Giardina
    Pages 93-102
  7. Chad A. Corcoran, Ying Huang, M. Saeed Sheikh
    Pages 131-150
  8. Bora E. Baysal
    Pages 151-162
  9. Stefanie Zanssen
    Pages 163-191
  10. J. Lima, V. Máximo, P. Soares, R. Portugal, S. Guimarães, M. Sobrinho-Simões
    Pages 193-209
  11. Stephen J. Ralph, Jiri Neuzil
    Pages 211-249
  12. Gopinath Sutendra, Evangelos D. Michelakis
    Pages 251-264
  13. Volkmar Weissig, Gerard G. M. D’Souza, Shing-Ming Cheng, Sarathi Boddapati
    Pages 265-279
  14. Back Matter
    Pages 281-289

About this book


Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.


Citrate Metabolism Lipogenic Switch Mitochondria Mitochondrial Nanotechnology Mitochondrial Respiration Oncocytomas Prostate Cancer Proteomics Warburg apoptosis tumorigenesis

Bibliographic information

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