© 2009

Cardiac Bioelectric Therapy

Mechanisms and Practical Implications

  • Igor R. Efimov
  • Mark W. Kroll
  • Patrick J. Tchou


  • Over 500 illustrations

  • Historical Overview of Pacing and Defibrillation


Table of contents

  1. Front Matter
    Pages i-xxiii
  2. History

    1. Srijoy Mahapatra
      Pages 3-13
    2. Hana Akselrod, Mark W. Kroll, Michael V. Orlov
      Pages 15-40
    3. Galina Kichigina, José Jalife
      Pages 41-59
  3. Theory of Electric Stimulation and Defibrillation

    1. Deborah L. Janks, Bradley J. Roth
      Pages 63-83
    2. Natalia Trayanova, Gernot Plank
      Pages 85-109
    3. Leslie Tung
      Pages 111-132
    4. Wanda Krassowska Neu, John C. Neu
      Pages 133-161
  4. Electrode Mapping of Defibrillation

  5. Optical Mapping of Stimulation and Defibrillation

    1. Vinod Sharma
      Pages 221-254
    2. John P. Wikswo, Bradley J. Roth
      Pages 283-330
    3. Crystal M. Ripplinger, Igor R. Efimov
      Pages 331-356
    4. Stephen B. Knisley, Herman D. Himel IV, John H. Dumas III
      Pages 357-380
  6. Methodology

    1. Craig S. Henriquez, Wenjun Ying
      Pages 401-421
    2. Edward J. Berbari, Haris Sih
      Pages 423-439
    3. Vladimir P. Nikolski, Igor R. Efimov
      Pages 441-455
  7. Implications for Implantable Devices

    1. Mark W. Kroll, Charles D. Swerdlow
      Pages 459-492

About this book


Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The history of the successful development of bioelectric therapies includes the development of experimental and theoretical methodologies, novel bioengineering approaches and state-of-the-art clinical implantable device therapies. This volume will present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy.

Igor R. Efimov, Ph.D., is Associate Professor of Biomedical Engineering, Washington University, St. Louis, Missouri.

Mark W. Kroll, Ph.D., is Adjunct Professor Biomedical Engineering, California Polytechnic University and University of Minnesota..

Patrick J. Tchou, M.D. is  in the Section of Cardiac Electrophysiology and Pacing at the Cleveland Clinic in Cleveland, Ohio.



arrhythmia cardiac pacing electrophysiology heart pacemaker physiology

Editors and affiliations

  • Igor R. Efimov
    • 1
  • Mark W. Kroll
    • 2
  • Patrick J. Tchou
    • 3
  1. 1.Department of Biomedical EngineeringWashington UniversitySt. LouisUSA
  2. 2.Department of Biomedical EngineeringUniversity of MinnesotaMinneapolisUSA
  3. 3.Cleveland Clinic FoundationClevelandOH

Bibliographic information

  • Book Title Cardiac Bioelectric Therapy
  • Book Subtitle Mechanisms and Practical Implications
  • Editors Igor R. Efimov
    Mark W. Kroll
    Patrick Tchou
  • DOI
  • Copyright Information Springer US 2009
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-0-387-79402-0
  • Softcover ISBN 978-1-4899-7912-4
  • eBook ISBN 978-0-387-79403-7
  • Edition Number 1
  • Number of Pages XXIII, 634
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


From the reviews:

"This book discusses the background of the theory and methodology that drive current pacing and defibrillation strategies. … The most likely readers are electrophysiologists, research scientists in the field of cardiac bioelectric therapy, or physician-scientists with an interest in this field. … This is an extremely thorough book on the mechanisms that drive the current clinical utility of pacemakers and defibrillators. It will be a useful reference for many electrophysiologists and researchers in the field." (Louis A Salvaggio, Doody’s Review Service, February, 2009)