© 2008

Molecular Mechanisms of Parasite Invasion

Subcellular Biochemistry

  • Barbara A. Burleigh
  • Dominique Soldati-Favre

Part of the Subcellular Biochemistry book series (SCBI, volume 47)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Tools and Experimental Approaches

  3. Receptor-Ligand Interaction

    1. Vern B. Carruthers, Fiona M. Tomley
      Pages 33-45
    2. Manoj T. Duraisingh, Tiffany DeSimone, Cameron Jennings, Philippe Refour, Chenwei Wu
      Pages 46-57
  4. Signaling Pathways

    1. Kisaburo Nagamune, Silvia N. Moreno, Eduardo N. Chini, L. David Sibley
      Pages 70-81
  5. Actin Dynamics: Host and Parasite

    1. Steven P. O’Hara, Aaron J. Small, Xian-Ming Chen, Nicholas F. LaRusso
      Pages 92-100
    2. Renato A. Mortara, Walter K. Andreoli, Maria Cecília D. C. Fernandes, Claudio V. da Silva, Adriana B. Fernandes, Carolina L’Abbate et al.
      Pages 101-109
    3. Kai Matuschewski, Herwig Schüler
      Pages 110-120
  6. Proteases

    1. Timothy J. Dowse, Konstantinos Koussis, Michael J. Blackman, Dominique Soldati-Favre
      Pages 121-139
  7. The Parasitophorous Vacuole

    1. G. Adam Mott, Barbara A. Burleigh
      Pages 165-173
    2. Robert Lodge, Albert Descoteaux
      Pages 174-181
  8. Penetrating Biological Barriers

    1. Ute Frevert, Ivan Usynin, Kerstin Baer, Christian Klotz
      Pages 182-197
    2. Antonio Barragan, Niclas Hitziger
      Pages 198-207
    3. Frédéric Delbac, Valérie Polonais
      Pages 208-220
    4. Shahram Solaymani-Mohammadi, William A. Petri Jr.
      Pages 221-232
  9. Back Matter
    Pages 233-237

About this book


All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.


dynamics infection membrane parasite proteins protozoa

Editors and affiliations

  • Barbara A. Burleigh
    • 1
  • Dominique Soldati-Favre
    • 2
    • 3
  1. 1.Department of Immunology and Infectious DiseasesHarvard School of Public HealthBostonUSA
  2. 2.Department of Biological SciencesImperial CollegeLondonUK
  3. 3.Département de Microbiologie et Medecine MoléculaireUniversité de GenèveGeneveSwitzerland

Bibliographic information

  • Book Title Molecular Mechanisms of Parasite Invasion
  • Book Subtitle Subcellular Biochemistry
  • Editors Barbara A. Burleigh
    Dominique Soldati
  • Series Title Subcellular Biochemistry
  • DOI
  • Copyright Information Springer New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-0-387-78266-9
  • Softcover ISBN 978-1-4419-2683-8
  • eBook ISBN 978-0-387-78267-6
  • Series ISSN 0306-0225
  • Edition Number 1
  • Number of Pages XX, 237
  • Number of Illustrations 48 b/w illustrations, 4 illustrations in colour
  • Topics Biomedicine, general
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Consumer Packaged Goods


From the reviews:

"An environment in which there is extensive knowledge of the DNA, RNA and protein of key parasites and of human cells. … Readers of this book will discover that while many of the exact mechanisms … adopted by different parasites. As someone working in this field I found this book enormously interesting and useful … . Active researchers and PhD students in this and affiliated fields will no doubt find this an essential resource for several years … ." (Kevin M. Tyler, Parasites and Vectors, Issue 2, May, 2009)