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Probability Models for DNA Sequence Evolution

  • RichardĀ Durrett

Part of the Probability and its Applications book series (PIA)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Richard Durrett
    Pages 1-52
  3. Richard Durrett
    Pages 53-82
  4. Richard Durrett
    Pages 83-124
  5. Richard Durrett
    Pages 125-160
  6. Richard Durrett
    Pages 161-190
  7. Richard Durrett
    Pages 191-247
  8. Richard Durrett
    Pages 249-312
  9. Richard Durrett
    Pages 313-354
  10. Richard Durrett
    Pages 355-397
  11. Back Matter
    Pages 399-431

About this book

Introduction

How is genetic variability shaped by natural selection, demographic factors, and random genetic drift? To approach this question, we introduce and analyze a number of probability models beginning with the basics, and ending at the frontiers of current research. Throughout the book, the theory is developed in close connection with examples from the biology literature that illustrate the use of these results. Along the way, there are many numerical examples and graphs to illustrate the conclusions.

This is the second edition and is twice the size of the first one. The material on recombination and the stepping stone model have been greatly expanded, there are many results form the last five years, and two new chapters on diffusion processes develop that viewpoint. This book is written for mathematicians and for biologists alike. No previous knowledge of concepts from biology is assumed, and only a basic knowledge of probability, including some familiarity with Markov chains and Poisson processes. The book has been restructured into a large number of subsections and written in a theorem-proof style, to more clearly highlight the main results and allow readers to find the results they need and to skip the proofs if they desire.

Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of eight books and 160 research papers, most of which concern the use of probability models in genetics and ecology. He is the academic father of 39 Ph.D. students and was recently elected to the National Academy of Sciences.

Keywords

Computerassistierte Detektion DNA Evolution Variance diffusion processes genome rearrangement natural selection population genetics recombination

Authors and affiliations

  • RichardĀ Durrett
    • 1
  1. 1.Dept. MathematicsCornell UniversityIthacaU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-78168-6
  • Copyright Information Springer-Verlag New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-0-387-78168-6
  • Online ISBN 978-0-387-78169-3
  • Series Print ISSN 1431-7028
  • Buy this book on publisher's site
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