© 2007



Part of the Medical Intelligence Unit book series (MIUN)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Anders Wikby, Frederick Ferguson, Jan Strindhall, Rosalyn J. Forsey, Tamas Fulop, Sine Reker Hadrup et al.
    Pages 1-14
  3. Katsuiku Hirokawa, Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa
    Pages 15-23
  4. Inmaculada Gayoso, M. Luisa Pita, Esther Peralbo, Corona Alonso, Olga DelaRosa, Javier G. Casado et al.
    Pages 24-33
  5. Wayne A. Mitchell, Richard Aspinall
    Pages 68-79
  6. Erminia Mariani, Adriana Rita Mariani, Andrea Facchini
    Pages 92-105
  7. Dietmar Herndler-Brandstetter, Beatrix Grubeck-Loebenstein
    Pages 106-120
  8. Hajo Haase, Lothar Rink
    Pages 121-128
  9. Elissaveta J. Naumova, Milena I. Ivanova
    Pages 137-153
  10. Calogero Caruso, Carmela Rita Balistreri, Antonino Crivello, Giusi Irma Forte, Maria Paola Grimaldi, Florinda Listì et al.
    Pages 154-173
  11. Dawn J. Mazzatti, Robin Longdin, Graham Pawelec, Jonathan R. Powell, Rosalyn J. Forsey
    Pages 174-190
  12. Back Matter
    Pages 191-194

About this book


Human immunosenescence contributes to morbidity and mortality in later life. The age-associated increasing incidence of cancer and cardiovascular disease plateaus at around 80 years of age in industrialised countries, but death due to infectious disease continues to increase up to 100 years of age and beyond. Understanding the reasons for age-associated alterations to protective immunity in the elderly would facilitate the development of interventions to reconstitute appropriate immune function, increase responsiveness to vaccination and extend healthspan. The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age.


Immunosenescence age aging assessment autoimmune disease cancer infectious diseases morbidity senescence

Authors and affiliations

  1. 1.University of Tübingen Center for Medical Research (ZMF)TübingenGermany

Bibliographic information

  • Book Title Immunosenescence
  • Editors Graham Pawelec
  • Series Title Medical Intelligence Unit
  • DOI
  • Copyright Information Springer New York 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-0-387-76840-3
  • Softcover ISBN 978-1-4419-2639-5
  • eBook ISBN 978-0-387-76842-7
  • Edition Number 1
  • Number of Pages XVIII, 194
  • Number of Illustrations 41 b/w illustrations, 5 illustrations in colour
  • Topics Biomedicine, general
  • Buy this book on publisher's site
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From the reviews:

“The book covers the basic biology of cell-mediated immunity decline, the consequences of the declined immune system, and interventional therapeutic approaches aiming to correct or reverse the aged immune system. … The book ends with insightful review on therapeutic strategies aiming to correct or reverse immunosenescence. Overall, the book is very well written and should be recommended reading for cell biologists, immunologists, and physician scientists interested in the current scope of understanding immunosenscence and opportunities to explore therapeutic strategies for its correction.” (Yang Zhou, Clinical Infectious Diseases, December, 2012)