© 2008

Reelin Glycoprotein

Structure, Biology and Roles in Health and Disease

  • S. Hossein Fatemi

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Cheng-Chiu Huang, Gabriella D’Arcangelo
    Pages 1-13
  3. Yves Jossin
    Pages 37-47
  4. Junichi Takagi
    Pages 57-67
  5. Eric C. Olson, Christopher A. Walsh
    Pages 89-105
  6. Rosalinda C. Roberts, Emma Perez-Costas
    Pages 107-125
  7. Toshio Ohshima
    Pages 127-139
  8. Robert F. Hevner
    Pages 141-158
  9. Eckart Förster, Shanting Zhao, Michael Frotscher
    Pages 159-169
  10. Shenfeng Qiu, Edwin John Weeber
    Pages 171-191
  11. Jonathan A. Cooper, Nathaniel S. Allen, Libing Feng
    Pages 193-216
  12. George D. Pappas, C. Sue Carter
    Pages 217-226
  13. Manuel Álvarez-Dolado
    Pages 227-235
  14. Thomas Ringstedt
    Pages 237-250
  15. Brigitte Samama, Nelly Boehm
    Pages 251-261
  16. Jean-Marc Mienville
    Pages 263-277
  17. Françoise Bleicher, Henry Magloire, Marie-Lise Couble, Jean-Christophe Maurin
    Pages 279-290

About this book


Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.


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Editors and affiliations

  • S. Hossein Fatemi
    • 1
  1. 1.Medical SchoolUniversity of MinnesotaMinneapolisUSA

Bibliographic information

  • Book Title Reelin Glycoprotein
  • Book Subtitle Structure, Biology and Roles in Health and Disease
  • Editors S.H. Fatemi
  • DOI
  • Copyright Information Springer New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-0-387-76760-4
  • Softcover ISBN 978-1-4899-8695-5
  • eBook ISBN 978-0-387-76761-1
  • Edition Number 1
  • Number of Pages XXIII, 443
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. … The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. … This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody’s Review Service, July, 2009)

“The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. … The book consists of 28 chapters presented by international group of experts. … book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders.” (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)