© 2007

Axon Growth and Guidance

  • Dominique Bagnard

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 621)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Céline Bouquet, Fatiha Nothias
    Pages 1-16
  3. Simon W. Moore, Marc Tessier-Lavigne, Timothy E. Kennedy
    Pages 17-31
  4. Michael Reber, Robert Hindges, Greg Lemke
    Pages 32-49
  5. Eric Koncina, Lise Roth, Bertand Gonthier, Dominique Bagnard
    Pages 50-64
  6. Alain Chédotal
    Pages 65-80
  7. Tina Ruediger, Juergen Bolz
    Pages 104-114
  8. Frédéric Charron, Marc Tessier-Lavigne
    Pages 116-133
  9. Michael Piper, Francis van Horck, Christine Holt
    Pages 134-143
  10. Carmine Guirland, James Q. Zheng
    Pages 144-154
  11. Anabel R. Learte, Alicia Hidalgo
    Pages 156-166
  12. Back Matter
    Pages 167-169

About this book


The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years. This book proposes an exhaustive and updated view ofthe current knowledge ofthe molecular and cellular mechanisms ensuring axon growth and guidance. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the features ofa growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one ofthe most fantastic developmental achievements: the nervous system wiring.


Nervous System axon cell lipide membrane neurotransmitter receptor research

Editors and affiliations

  • Dominique Bagnard
    • 1
  1. 1.Laboratoire de Neurobiologie du Developpement et de la Regeneration (LNDR)Centre de Neurochimie de CNRSStrasbourgFrance

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