© 2008

Recent Advances in Retinal Degeneration

  • Robert E. Anderson
  • Matthew M. LaVail
  • Joe G. Hollyfield

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Table of contents

  1. Front Matter
    Pages I-XXXIV
  2. Keynote Lectures

    1. Front Matter
      Pages 1-1
  3. Neuroprotection

    1. Front Matter
      Pages 37-37
    2. Junping Chen, Swanand Patil, Sudipta Seal, James F. McGinnis
      Pages 53-59
    3. Yogita Kanan, Anne Kasus Jacobi, Kjell Sawyer, David S. Mannel, Joyce Tombran Tink, Muayyad R. Al-Ubaidi
      Pages 61-67
    4. Yun-Zheng Le, Lixin Zheng, Yuwei Le, Edmund B. Rucker III, Robert E. Anderson
      Pages 69-74
    5. Markus Thiersch, Wolfgang Raffelsberger, Enrico Frigg, Marijana Samardzija, Patricia Blank, Olivier Poch et al.
      Pages 75-85
  4. Gene Therapy and Neuroprotection

    1. Front Matter
      Pages 87-87
    2. Alexis-Pierre Bemelmans, Corinne Kostic, Maité Cachafeiro, Sylvain V. Crippa, Dana Wanner, Meriem Tekaya et al.
      Pages 89-95
    3. Dibyendu Chakraborty, Patrick Whalen, Alfred S. Lewin, Muna I. Naash
      Pages 97-106
    4. Marina S. Gorbatyuk, William W. Hauswirth, Alfred S. Lewin
      Pages 107-112
    5. John J. Alexander, William W. Hauswirth
      Pages 121-128
    6. Kristina Narfstrô m, Mathias Seeliger, Chooi-May Lai, Vaegan, Martin Katz, Elizabeth P. Rakoczy et al.
      Pages 139-146

About this book


Retinal Degenerations is the result of The International Symposium on Retinal Degeneration which has become perhaps the most important research meeting in the field. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, generics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.

Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early of congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.


development diseases endothelium etiology gene expression genetics hearing inflammation macular degeneration membrane mouse neuroprotection research retina stem cells

Editors and affiliations

  • Robert E. Anderson
    • 1
  • Matthew M. LaVail
    • 2
  • Joe G. Hollyfield
    • 3
  1. 1.University of Oklahoma Health Science CtrOklahoma CityUSA
  2. 2.USCF School of MedicineSan FranciscoUSA
  3. 3.Cole Eye Institute The Cleveland Clinic FoundationClevelandUSA

Bibliographic information

  • Book Title Recent Advances in Retinal Degeneration
  • Editors Robert E. Anderson
    Matthew M. LaVail
    Joe G. Hollyfield
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-0-387-74902-0
  • Softcover ISBN 978-1-4419-2577-0
  • eBook ISBN 978-0-387-74904-4
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XXXIV, 424
  • Number of Illustrations 114 b/w illustrations, 3 illustrations in colour
  • Topics Ophthalmology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"This edited book is the proceedings of the symposium on Retinal Degeneration … . The purpose is to disseminate the latest research findings in the field of retinal degenerations from the symposium participants … . The book is written for scientists and trainees in the field of retinal degenerations. The editors are experts in this field and many of the chapter authors are experts in their respective areas. … This is a must-have reference for the shelf of scientists interested in retinal degeneration." (Artur V Cideciyan, Doody’s Review Service, April, 2008)