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Breast Cancer Chemosensitivity

  • Dihua Yu
  • Mien-Chie Hung

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 608)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez, Gabriel N. Hortobagyi
    Pages 1-22
  3. David J. McConkey
    Pages 31-51
  4. Kimberly A. Scata, Wafik S. El-Deiry
    Pages 70-86
  5. Xianke Zeng, Douglas Yee
    Pages 101-112
  6. Robert B. Dickson, T. B. Deb
    Pages 113-118
  7. Matthew H. Herynk, Suzanne A. W. Fuqua
    Pages 130-143
  8. Yong Liao, Dihua Yu, Mien-Chie Hung
    Pages 144-169
  9. Back Matter
    Pages 171-175

About this book

Introduction

In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.

Keywords

BRCA Breast Cancer Chemosensitivity DNA Resistance genes molecular mechanisms

Editors and affiliations

  • Dihua Yu
    • 1
  • Mien-Chie Hung
    • 2
  1. 1.Department of Surgical OncologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of Molecular and Cellular OncologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

Bibliographic information

Industry Sectors
Pharma
Health & Hospitals
Biotechnology