© 2008

Targeted Therapies in Cancer

Myth or Reality?

  • Francesco Colotta
  • Alberto Mantovani


  • Presents findings from the 2005 meeting Targeted Therapies in Cancer: Myth or Reality

  • Reviews the move from empiricism to molecular targeted therapies and its effect on the development of new cancer therapies

  • Offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 610)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Giulio Giorello
    Pages 1-4
  3. Francesco Colotta
    Pages 19-42
  4. Patrizia Carpinelli, Jürgen Moll
    Pages 54-73
  5. Carmelo Carlo-Stella, Cristiana Lavazza, Antonino Carbone, Alessandro M. Gianni
    Pages 100-111
  6. Alberto Mantovani, Federica Marchesi, Chiara Porta, Paola Allavena, Antonio Sica
    Pages 112-127
  7. Runa Speer, Julia Wulfkuhle, Virginia Espina, Robyn Aurajo, Kirsten H. Edmiston, Lance A. Liotta et al.
    Pages 177-186
  8. Back Matter
    Pages 187-191

About this book


In September 2005 an International Meeting on “Targeted Therapies in Cancer: Myth or Reality” was held in Milan. This successful Meeting was intended to represent a forum for scientists and clinicians working in cancer drug discovery and therapy to share their reflections and experiences on how the paradigm shift from empiricism to molecular targeted therapies is contributing to the translation of basic knowledge into new therapies for cancer patients. This book collects the contributions given by scientists and clinicians, from Academia and Industry, who participated to this Meeting.

We hope that this book contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures. Time is therefore ripe for a critical cultural reflection on the state of the art, prospects and limitations. Ultimately, is targeted therapy in cancer a myth or a reality?


2005 International Meeting Cancer Microarray angiogenesis evolution in vitro in vivo molecular determinants remedies targeted therapy therapy translation tumor growth

Editors and affiliations

  • Francesco Colotta
    • 1
  • Alberto Mantovani
    • 2
  1. 1.Nerviano Medical SciencesNerviano (Milano)Italy
  2. 2.Istituto Clinico Humanitas and Institute of PathologyUniversity of MilanRozzano, MilanoItaly

Bibliographic information

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