© 2008

Transcriptional Regulation by Neuronal Activity

To the Nucleus and Back

  • Serena M. Dudek

Table of contents

  1. Front Matter
    Pages I-XII
  2. Activity-regulated Transcription: Getting to the Nucleus

    1. Front Matter
      Pages 1-1
    2. Tarciso A.F. Velho, Claudio V. Mello
      Pages 3-26
    3. Bryen A. Jordan, Edward B. Ziff
      Pages 27-50
    4. Mark F. Yeckel, Amanda A. Sleeper, John S. Fitzpatrick, Daniel N. Hertle, Anna M. Hagenston, Robin T. Garner
      Pages 73-89
    5. J. Paige Adams, Rachel A. Robinson, Serena M. Dudek
      Pages 91-110
    6. Natalia Gomez-Ospina, Ricardo Dolmetsch
      Pages 111-123
  3. Activity-regulated Transcription: Gene Regulation

  4. Activity-regulated Transcription: Role in Nervous System Function

    1. Front Matter
      Pages 251-251
    2. Cynthia Barber, J. Troy Littleton
      Pages 253-275
    3. Hai-Ying Mary Cheng, Karl Obrietan
      Pages 313-336

About this book


Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field – specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function.

About the Author:

Serena M. Dudek, Ph.D. is best known for her seminal work describing Long-term synaptic Depression (LTD) in the hippocampus. Dr. Dudek heads the Synaptic and Developmental Plasticity Group at the National Institute of Environmental Health Sciences, where her laboratory studies the cellular mechanisms of synaptic plasticity in the adult and developing mammalian brain. Although once a critic of the proposed necessity of transcription for maintenance of synaptic plasticity, Dr. Dudek now devotes much of her time to work on the topic.


Nervous System Neuroscience gene expression gene regulation gene transcription neurons plasticity synaptic plasticity

Editors and affiliations

  • Serena M. Dudek
    • 1
  1. 1.Laboratory of NeurobiologySynaptic & Developmental Plasticity Group NIEHS/NIHResearch Triangle ParkUSA

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