© 2007

Oxidative Damage to Nucleic Acids

  • Mark D. Evans
  • Marcus S. Cooke


  • Provides a comprehensive and detailed analysis of the topic of nucleic acid oxidation from the perspectives of basic science and biological relevance


Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Jean Cadet, Thierry Douki, Carine Badouard, Alain Favier, Jean-Luc Ravanat
    Pages 1-13
  3. Clare L. Hawkins, David I. Pattison, Matthew Whiteman, Michael J. Davies
    Pages 14-39
  4. Yusaku Nakabeppu, Mehrdad Behmanesh, Hiroo Yamaguchi, Daisuke Yoshimura, Kunihiko Sakumi
    Pages 40-53
  5. Sophie Couvé-Privat, Alexander A. Ishchenko, Jacques Laval, Murat Saparbaev
    Pages 54-66
  6. Arne Klungland, Jon K. Laerdahl, Torbjørn Rognes
    Pages 67-80
  7. Jason L. Parsons, Emma Boswell, Grigory L. Dianov
    Pages 81-90
  8. David Mitchell, Rita Ghosh
    Pages 91-99
  9. Torsten Richter, Thomas von Zglinicki
    Pages 100-108
  10. Lene Juel Rasmussen, Keshav K. Singh
    Pages 109-122
  11. V. Prakash Reddy, Ayse Beyaz, George Perry, Marcus S. Cooke, Lawrence M. Sayre, Mark A. Smith
    Pages 123-140
  12. Ryszard Olinski, Marek Foksinski, Barbara Tudek
    Pages 153-166
  13. H. Kasai, T. Hirano, K. Kawai, Y. Tsurudome, H. Itoh, D. Himeji et al.
    Pages 178-187
  14. Peter C. Dedon, Marita C. Barth
    Pages 188-206
  15. Back Matter
    Pages 225-228

About this book


This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, we recognize additionally the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. The primary audience for the book would be research scientists and advanced postgraduate students, the book may also be of interest to clinicians with strong research interests. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before.


Aging Carcinogenesis DNA Neurological Disease Nucleotide Nucleotides Oxidation Oxidative Damage Promoter Purine Telomere

Editors and affiliations

  • Mark D. Evans
    • 1
  • Marcus S. Cooke
    • 2
  1. 1.Radiation and Oxidative Stress Group Department of Cancer Studies and Molecular Medicine RKCSB, Leicester Royal InfirmaryUniversity of LeicesterLeicesterUK
  2. 2.Department of Cancer Studies and Molecular Medicine and Department of GeneticsUniversity of LeicesterLeicesterUK

About the editors

Drs. Mark D. Evans and Marcus S. Cooke are academics at the University of Leicester, U.K. Collectively we have around 30-35 years of research experience in the field of free radical biochemistry, most of it in relation to damage to the genome. Mark did his Bachelor’s degree at Brunel University, Uxbridge, U.K., his PhD at Louisiana State University, Baton Rouge, USA and has worked his way through the ranks at The University of Leicester via several postdocs to become a tenured non-clinical lecturer in the Department of Cancer Studies and Molecular Medicine (CSMM). Marcus did his Bachelor’s degree at John Moore’s University, Liverpool and both his MSc and PhD at University of Leicester. Marcus also worked his way through the ranks to become a tenured non-clinical senior lecturer in CSMM, but also holds a joint appointment in the world renowned Department of Genetics at Leicester, home of DNA fingerprinting. 2003 saw Marcus receive the Young Scientist Prize from the European Environmental Mutagen Society for his work on DNA damage. Our pedigree demonstrates that we are in a prime position to evaluate the cutting edge of research in the field of DNA oxidation and, in acknowledgement of this, the world’s leaders in their respective fields agreed to contribute to the book.

Bibliographic information

  • Book Title Oxidative Damage to Nucleic Acids
  • Editors Mark D. Evans
    Marcus S. Cooke
  • Series Title Molecular Biology Intelligence Unit
  • DOI
  • Copyright Information Springer New York 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-0-387-72973-2
  • Softcover ISBN 978-1-4419-2503-9
  • eBook ISBN 978-0-387-72974-9
  • Edition Number 1
  • Number of Pages XVII, 228
  • Number of Illustrations 67 b/w illustrations, 7 illustrations in colour
  • Topics Biochemistry, general
  • Buy this book on publisher's site
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