© 2007

Mucosal Immune Defense: Immunoglobulin A

  • Charlotte Slayton Kaetzel

Table of contents

  1. Front Matter
    Pages i-xv
  2. Jenny M. Woof
    Pages 1-24
  3. Jo Spencer, Laurent Boursier, Jonathan D. Edgeworth
    Pages 25-42
  4. Charlotte Slayton Kaetzel, Maria E. C. Bruno
    Pages 43-89
  5. H. Craig Morton
    Pages 90-110
  6. Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg
    Pages 111-143
  7. Michael W. Russell
    Pages 144-172
  8. Armelle Phalipon, Blaise Corthésy
    Pages 183-202
  9. Nicholas J. Mantis, Blaise Corthésy
    Pages 203-220
  10. Per Brandtzaeg, Finn-Eirik Johansen
    Pages 221-268
  11. Dennis W. Metzger
    Pages 269-290
  12. Charu Kaushic, Charles R. Wira
    Pages 291-320
  13. Jiri Mestecky, Lennart Hammarström
    Pages 321-344
  14. Esther M. Yoo, Koteswara R. Chintalacharuvu, Sherie L. Morrison
    Pages 390-415
  15. Back Matter
    Pages 417-433

About this book


Antibodies of the IgA class form the front line of immune defense at mucosal surfaces lining the gastrointestinal, respiratory and genital tracts. These IgA antibodies promote peaceful co-existence with beneficial microorganisms, such as gut bacteria that assist in digestion and nutrient production, while selectively neutralizing pathogenic microorganisms and harmful environmental substances. This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer. The final chapters describe state-of-the art applications of molecular genetics for the production of vaccines and therapeutics targeting IgA. The unique focus on IgA, the most abundant molecule in the mucosal immune system, differentiates this book from more general texts in the area of mucosal immunology. This book should be useful for researchers, educators, clinicians and students interested in a concise source of up-to-date information on the central role of IgA in mucosal immune defense.


Antigen antibody antimicrobial cell cell culture diseases gene gene regulation immunobiology immunoglobulin pathogenesis polymer research

Editors and affiliations

  • Charlotte Slayton Kaetzel
    • 1
  1. 1.University of KentuckyLexingtonUSA

About the editors

Dr. Charlotte Kaetzel received her PhD and postdoctoral training in biochemistry and cell biology from the University of Maryland. Her introduction into the world of immunology came with her first faculty appointment in 1983 in the Department of Pathology at Case Western Reserve University in Cleveland. Under the mentorship of department chair Michael Lamm, a world leader in IgA biology, she applied the emerging tools of biochemistry and molecular biology to the study of IgA transport across epithelial cells of the gastrointestinal and respiratory tracts. Now a professor in the Department of Microbiology, Immunology and Molecular Genetics at the University of Kentucky College of Medicine, Dr. Kaetzel’s research is devoted to understanding the basic science and clinical relevance of IgA in maintenance of homeostasis in the gastrointestinal tract. Her research has been funded by the National Institutes of Health and the Crohn’s and Colitis Foundation of America. Dr. Kaetzel has served on advisory panels for a number governmental agencies and private foundations, and as an Associate Editor for The Journal of Immunology, the official journal of the American Association of Immunologists. A charter member of the Society for Mucosal Immunology, Dr. Kaetzel is currently serving as Associate Editor for its flagship journal, Mucosal Immunology.

Bibliographic information

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