TNF Receptor Associated Factors (TRAFs)

  • Hao Wu

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Juan M. Zapata, Vanesa Martínez-García, Sophie Lefebvre
    Pages 1-24
  3. Soo Young Lee, Yongwon Choi
    Pages 25-31
  4. Ping-Yee Billie Au, Wen-Chen Yeh
    Pages 32-47
  5. Jeannie Q. He, Gagik Oganesyan, Supriya K. Saha, Brian Zarnegar, Genhong Cheng
    Pages 48-59
  6. Valérie Kedinger, Marie-Christine Rio
    Pages 60-71
  7. Jun-ichiro Inoue, Jin Gohda, Taishin Akiyama
    Pages 72-79
  8. Gabriel Pineda, Chee-Kwee Ea, Zhijian J. Chen
    Pages 80-92
  9. Jee Y. Chung, Miao Lu, Qian Yin, Hao Wu
    Pages 93-113
  10. Kathryn R. Ely, Ramadurgam Kodandapani, ShuangDing Wu
    Pages 114-121
  11. Jee Y. Chung, Miao Lu, Qian Yin, Su-Chang Lin, Hao Wu
    Pages 122-130
  12. Gail A. Bishop, Carissa R. Moore, Ping Xie, Laura L. Stunz, Zachary J. Kraus
    Pages 131-151
  13. Bryant G. Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe, Jürg J. Jacoby
    Pages 152-159
  14. Paula S. Norris, Carl F. Ware
    Pages 160-172
  15. Vishal Soni, Ellen Cahir-McFarland, Elliott Kieff
    Pages 173-187
  16. Juan M. Zapata, Sophie Lefebvre, John C. Reed
    Pages 188-201
  17. Back Matter
    Pages 203-206

About this book


It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer.

TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.


biological functions cell biology phylogeny regulation signal transduction

Editors and affiliations

  • Hao Wu
    • 1
  1. 1.Department of BiochemistryWeill Medical College of Cornell UniversityNew YorkUSA

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