Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy

  • Stanley P. L. Leong

Part of the Cancer Treatment and Research book series (CTAR, volume 135)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Marlys H. Witte, Kimberly Jones, Michael Bernas, Charles L. Witte
    Pages 1-16
  3. Jörg Wilting, Maria Papoutsi, Kerstin Buttler, Jürgen Becker
    Pages 17-24
  4. Michael Dictor, Sofia Mebrahtu, Manuel Selg, Zerina Lokmic, Lydia Sorokin
    Pages 25-37
  5. Mauro Andrade, Alfredo Jacomo
    Pages 55-77
  6. Adriano Piris, Martin C. Mihm
    Pages 119-127
  7. Michael M. Lizardo, Ian C. MacDonald, Alan B. Tuck, Ann F. Chambers
    Pages 157-165
  8. Katharina E. Effenberger, Wulf Sienel, Klaus Pantel
    Pages 167-175
  9. Hiroya Takeuchi, Minoru Kitago, David S. B. Hoon
    Pages 177-184
  10. Jochen A. Werner
    Pages 203-207
  11. Stanley P. L. Leong, Blake Cady, David M. Jablons, Julio Garcia-Aguilar, Douglas Reintgen, Jochen A. Werner et al.
    Pages 209-221
  12. Rongxiu Zheng, Jorgen Kjaergaard, Walter T. Lee, Peter A. Cohen, Suyu Shu
    Pages 223-237
  13. Harold J. Wanebo, David Berz, Anthony Mega
    Pages 239-255
  14. Michalis V. Karamouzis, Athanassios Argiris
    Pages 257-275
  15. Claus Garbe, Selma Ugurel, Katharina C. Kähler, Axel Hauschild, Dirk Schadendorf
    Pages 277-292
  16. Back Matter
    Pages 297-309

About this book


Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process.

· Molecular imaging advances help to localize early cancers more precisely.

· Current status of the immune responses in the draining lymph nodes against cancer is summarized.

· New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment.

In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.


Series editor's comments:

"Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process."

Steven T. Rosen, MD

Series Editor


angiogenesis apoptosis imaging lymphovascular metastasis

Editors and affiliations

  • Stanley P. L. Leong
    • 1
  1. 1.University of California San Francisco and UCSF Comprehensive Cancer Center at Mount ZionSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer US 2007
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-0-387-69218-0
  • Online ISBN 978-0-387-69219-7
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site
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