© 2010

Molecularly Targeted Therapy for Childhood Cancer

  • Peter J. Houghton
  • Robert J. Arceci

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Hematologic Malignancies

    1. Front Matter
      Pages 1-1
    2. Alejandro Gutierrez, A. Thomas Look
      Pages 19-30
    3. Patrick A. Brown, Carolyn A. Felix
      Pages 31-58
    4. Robert J. Arceci, Donald Small
      Pages 59-82
    5. Andrea Biondi, Anna Maria Testi, Brenda E. S. Gibson
      Pages 83-108
    6. Jeffrey W. Taub, Yubin Ge, Yaddanapudi Ravindranath
      Pages 109-122
    7. Jennifer O’Hara Lauchle, Benjamin S. Braun
      Pages 123-138
    8. Seth J. Corey, Jorge Cortes
      Pages 139-153
    9. Megan S. Lim, Mitchell S. Cairo
      Pages 177-213
    10. Michael Wang, Thomas G. Gross
      Pages 215-228
  3. Solid Tumors

    1. Front Matter
      Pages 299-299
    2. Richard J. Gilbertson
      Pages 291-304
    3. Yaël P. Mossé, John M. Maris
      Pages 351-371

About this book


Molecularly-Targeted Therapy for Childhood Cancer is a comprehensive exploration of the molecular aspects of childhood cancers that are currently being targeted therapeutically or are in the early phases of development. Each chapter describes key molecular characteristics of hematopoietic malignancies and solid tumors in children and young adults that are fundamental to the etiology, survival and drug resistance of these cancers as well as able to serve as tumor selective pathways for treatment. There has never been a more optimal time to explore the current and future use of molecularly targeted therapies in pediatric oncology. Conventional chemotherapeutic approaches have been dose intensified to such an extent that acute and late toxicities have reached maximal points while the rate of cure has slowed. The volume moves beyond conventional chemotherapeutic approaches to explore approaches that target tumor selective molecular and immunologic characteristics. The chapters further explore how such targeted therapies can begin to be integrated with conventional regimens in order to improve efficacy while reducing morbidity. While molecularly targeted therapies have generated great excitement in the world of oncology, their impact for pediatric patients may provide some of the greatest impact in part because of their developmental susceptibilities to conventional cytotoxic treatments. In addition, less toxic and more effective therapies hold great promise for improving the outcome of pediatric patients in developing countries where supportive care measures may not always be optimal. Molecularly-Targeted Therapy for Childhood Cancer is thus a timely first foray into the world of targeted, pathway directed treatment approaches for pediatric patients with cancer and brings us one step closer to the day when Paul Erhlich’s hope for therapeutic Magic Bullets becomes the conventional approach to cure.


biology cancer childhood development leukemia lymphoma physiology targeted therapy tissue tumor tumors

Editors and affiliations

  • Peter J. Houghton
    • 1
  • Robert J. Arceci
    • 2
  1. 1.Director, Center for Childhood Cancer, Nationwide Children’s HospitalThe Research InstituteColumbusUSA
  2. 2.Johns Hopkins The Bunting & Blaustein CaMedicine Kimmel Comprehensive Cancer CenBaltimoreUSA

Bibliographic information

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