Cardiac Mechanotransduction

  • Matti Weckström
  • Pasi Tavi

Table of contents

  1. Front Matter
    Pages I-XII
  2. Matti Weckström, Pasi Tavi
    Pages 1-7
  3. Clive M. Baumgarten
    Pages 8-27
  4. Jeffrey H. Omens, Andrew D. McCulloch, Ilka Lorenzen-Schmidt
    Pages 78-92
  5. Hiroshi Hasegawa, Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa, Issei Komuro
    Pages 93-105
  6. Klaus-Dieter Schlüter, Hans Michael Piper, Sibylle Wenzel
    Pages 106-119
  7. Sampsa Pikkarainen, Heikki Tokola, Heikki Ruskoaho
    Pages 134-144
  8. Back Matter
    Pages 145-147

About this book


For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con­ traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ­ ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "law" the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases. We editors hope that the large amount of knowledge compressed into the book's chapters forms a balanced treatment and that the text is easily approached by all who want to know what cardiac mechanotransduction is about. Matti Weckstrom and Pasi Tavi Oulu, Finland June 16. 2006 Ackno^vledgments The editors are grateful to all authors for their magnificent contributions and for their patience during compiling this book. This work was supported by the University of Oulu, the Biocenter Oulu and the Academy of Finland.


Cardiac Mechanotransduction Weckström biochemistry chemistry cytoskeleton heart ion channels membrane pathophysiology pharmacology physiology protein regulation

Authors and affiliations

  • Matti Weckström
    • 1
    • 2
  • Pasi Tavi
    • 3
    • 2
  1. 1.Department of Physical Sciences Division of BiophysicsUniversity of OuluOuluFinland
  2. 2.Biocenter OuluUniversity of OuluOuluFinland
  3. 3.Department of Physiology Division of BiophysicsUniversity of OuluOuluFinland

Bibliographic information

Industry Sectors
Health & Hospitals