Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

  • Peter Csermely
  • László Vígh

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 594)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. R. John Ellis
    Pages 1-13
  3. Rongmin Zhao, Walid A. Houry
    Pages 27-36
  4. Yuichiro Shimizu, Linda M. Hendershot
    Pages 37-46
  5. Marie-Pierre Hinault, Pierre Goloubinoff
    Pages 47-54
  6. Peter Csermely, Csaba Söti, Gregory L. Blatch
    Pages 55-63
  7. György Szabadkai, Rosario Rizzuto
    Pages 64-77
  8. Richard Voellmy, Frank Boellmann
    Pages 89-99
  9. László Vígh, Zsolt Török, Gábor Balogh, Attila Glatz, Stefano Piotto, Ibolya Horváth
    Pages 114-131
  10. Scott A. L. Hayward, Patricia A. Murray, Andrew Y. Gracey, Andrew R. Cossins
    Pages 132-142
  11. John H. Crowe
    Pages 143-158
  12. Zoltán Prohászka
    Pages 159-166
  13. Heather R. Brignull, James F. Morley, Richard I. Morimoto
    Pages 167-189
  14. Suzannah Rutherford, Jennifer R. Knapp, Peter Csermely
    Pages 190-197
  15. Back Matter
    Pages 199-201

About this book


We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes. The volume starts with an introduction to the concept of molecular chaperones in their original sense: R. John Ellis, the founder of the chaperone concept describes chaperones as mediators of correct assembly and/or misassembly of other macromolecular complexes. This sets the tone of the book, where later chapters give detailed examples of the richness of chaperone ac­ tion by hundreds of other proteins and membrane structures. The reader will learn the role of chaperone classes such as Hsp27 or Hsp90, the action of highly organized chaperone networks in various cellular compartments such as the ER or mitochondrial/ER networks as well as the molecular details of the signaling mechanisms leading to chaperone induction during stress. Various special stress defense mechanisms against oxidative stress or dryness will also be covered. Membranes comprise a surprising mixture of stability and dynamics in the cell. Their role in the regulation of the stress response has been accepted only slowly in the field. Two chapters summarize this important aspect of the stress response showing the importance of membrane hyperstructures, lipid species composition, protein/ membrane interactions and cold adaptation.


Activation Chaperone Chaperones Csermely Lipid Organelle Response Stress regulation

Editors and affiliations

  • Peter Csermely
    • 1
  • László Vígh
    • 2
  1. 1.Department of Medical ChemistrySemmelweis UniversityBudapestHungary
  2. 2.Institute of BiochemistryBiological Research Center of the Hungarian Academy of SciencesSzegedHungary

Bibliographic information

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