© 2007

Shh and Gli Signalling and Development


Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-x
  2. Carolyn E. Fisher, Sarah E.M. Howie
    Pages 1-11
  3. Silvia L. López, Andrés E. Carrasco
    Pages 12-22
  4. Paulette A. Zaki, Ben Martynoga, David J. Price
    Pages 23-35
  5. Min Tan, Yingchuan Qi, Mengsheng Qiu
    Pages 36-43
  6. Dwight Cordero, Minal Tapadia, Jill A. Helms
    Pages 44-57
  7. Martyn T. Cobourne, Isabelle Miletich, Paul T. Sharpe
    Pages 69-78
  8. Aimée Zuniga, Antonella Galli
    Pages 79-92
  9. Fabien Avaron, Amanda Smith, Marie-Andrée Akimenko
    Pages 93-106
  10. Susan Outram, Ariadne L. Hager-Theodorides, Tessa Crompton
    Pages 107-115
  11. Marilyn L. G. Lamm, Wade Bushman
    Pages 116-124
  12. Huimin Zhang, Ying Litingtung, Chin Chiang
    Pages 125-136
  13. Martin Rutter, Martin Post
    Pages 137-146
  14. Carolyn E. Fisher
    Pages 147-154
  15. Back Matter
    Pages 155-158

About this book


he hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fmger transcription factors. The Shh signalling pathway is well characterised in the develop­ ment of a number of vertebrate organ systems. It could indeed be argued that the Shh and Gli signalling may well be involved at some stage in the development of all the major organ systems in vertebrates. This volume rep­ resents a concerted drive to bring together *state of the art' reviews by lead­ ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap­ ters on the development of the central nervous system, skeletal struc­ tures, visceral organs, prostate, lung, immune system and the structures of the human face. The authors themselves span three major continents and multiple nationalities which admirably illustrates the worldwide nature of the science.


Invertebrate Vertebrate cell development invertebrates morphogenesis mouse transcription vertebrates

Authors and affiliations

  1. 1.Immunobiology Group MRC/UoE Centre for Inflammation ResearchThe Queen’s Medical Research InstituteEdinburghUK

Bibliographic information

  • Book Title Shh and Gli Signalling and Development
  • Editors Sarah Howie
    Carolyn Elaine Fisher
  • Series Title Molecular Biology Intelligence Unit
  • DOI
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-0-387-39956-0
  • Softcover ISBN 978-1-4419-2294-6
  • eBook ISBN 978-0-387-39957-7
  • Edition Number 1
  • Number of Pages XI, 158
  • Number of Illustrations 36 b/w illustrations, 4 illustrations in colour
  • Additional Information Jointly published with Landes Bioscience, Austin, TX, USA
  • Topics Developmental Biology
    Cell Biology
    Human Physiology
  • Buy this book on publisher's site
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