The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution

  • Brian K. Hall

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Discovery and Origins

    1. Front Matter
      Pages 1-1
    2. Brian K. Hall
      Pages 1-22
    3. Brian K. Hall
      Pages 63-116
    4. Brian K. Hall
      Pages 117-155
  3. Neural-Crest Derivatives

    1. Front Matter
      Pages 157-157
    2. Brian K. Hall
      Pages 159-177
    3. Brian K. Hall
      Pages 179-201
    4. Brian K. Hall
      Pages 203-246
  4. Abnormal Development and the Neural Crest

    1. Front Matter
      Pages 267-267
    2. Brian K. Hall
      Pages 269-293
  5. Back Matter
    Pages 329-400

About this book


The evolution of the neural crest sheds light on many of the oldest unanswered questions in developmental biology, including the role of germ layers in early embryogenesis, the development of the nervous system, how the vertebrate head arose developmentally and evolutionarily, and how growth factors and Hox genes direct cell differentiation and embryonic patterning. In this new edition of his essential work, The Neural Crest in Development and Evolution, Brian Hall has provided an up-to-date technically and intellectually rigorous synthesis of knowledge of all aspects of the neural crest and of neural crest cells (NCCs). These ten chapters are organized into three parts: (I) The discovery, and developmental and evolutionary origins of the neural crest; (II) cellular and tissue derivatives of the neural crest; (III) and tumors and birth defects arising from abnormal NCCs. The genetic and cellular bases for the identification of NCCs as early as during gastrulation, for induction of the neural crest, NCC delamination, migration and differentiation — understanding of all of which has increased enormously over the past decade — are discussed in depth in Part I. The evolutionary origin(s) of the neural crest is examined through an analysis of fossils, and of cell types, genes and gene networks in extant cephalochordates (amphioxus) and in ascidians. Four chapters grouped as Part II examine all aspects of neural crest-derived pigment cells, neurons, skeletal, cardiac and tooth-forming cells, with emphasis on how and when subpopulations of NCCs are specified and how their differentiation is controlled. The two chapters in Part III revisit NCC development in the context of tumors (neurocristopathies) and birth defects, with emphasis on genetic pathways, regulation of cell populations, and whether NCCs can be considered to be stem cells.

About the Author:
About the Author: Dr. Brian K. Hall has devoted much of his career to the study of the evolution and development of neural crest-derived skeletal tissues. He is a University Research Professor Emeritus at Dalhousie University in Halifax, Canada, a Visiting Distinguished Professor at Arizona State University in Tempe, a Fellow of the Royal Society of Canada, and a foreign fellow of the American Academy of Arts and Sciences.





Neuron Vertebrate behavior evolution genes migration

Editors and affiliations

  • Brian K. Hall
    • 1
    • 2
  1. 1.Department of BiologyDalhousie UniversityHalifaxCanada B3H4J1
  2. 2.Centre for Science and Society School of Life SciencesArizona State UniversityTempe

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