© 2006

Sphingolipid Biology

  • Yoshio Hirabayashi
  • Yasuyuki Igarashi
  • Alfred H. MerrillJr.

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill Jr.
      Pages 3-22
  3. Biosynthesis, Transport of Sphingolipids

    1. Front Matter
      Pages 23-23
    2. Jia Wei, Tokumbo Yerokun, Martina Liepelt, Amin Momin, Elaine Wang, Kentaro Hanada et al.
      Pages 25-47
    3. Irene Pankova-Kholmyansky, Anthony H. Futerman
      Pages 49-56
    4. Akemi Suzuki, Fumio Omae, Ayako Enomoto
      Pages 57-68
    5. Akio Kihara, Yasuyuki Igarashi
      Pages 95-106
    6. Kouichi Funato, Howard Riezman
      Pages 123-139
    7. Robert C. Dickson, Robert L. Lester
      Pages 141-150
  4. Generation and Degradation of Sphingolipid Signaling Molecules

    1. Front Matter
      Pages 151-151
    2. Kazuyuki Kitatani, L. Ashley Cowart, Yusuf A. Hannun
      Pages 153-165
    3. Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun
      Pages 167-181
    4. Michael Maceyka, Sergio E. Alvarez, Sheldon Milstien, Sarah Spiegel
      Pages 197-206
    5. Susumu Mitsutake, Tack-Joong Kim, Yasuyuki Igarashi
      Pages 207-218
    6. Julie D. Saba
      Pages 219-230

About this book


Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.


Activation Lipid base biology biosynthesis cell cell membrane enzymes membrane metabolism migration protein proteins saccharomyces cerevisiae synthesis

Editors and affiliations

  • Yoshio Hirabayashi
    • 1
  • Yasuyuki Igarashi
    • 2
  • Alfred H. MerrillJr.
    • 3
  1. 1.Brain Science InstituteThe Institute of Physical and Chemical Research (Riken)SaitamaJapan
  2. 2.Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life ScienceHokkaido UniversitySapporoJapan
  3. 3.School of Biology and the Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaUSA

Bibliographic information

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