Lymphocyte Trafficking in Health and Disease

  • Raffaele Badolato
  • Silvano Sozzani

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-x
  2. Lymphocyte trafficking: from immunology paradigms to disease mechanisms

  3. Physiology of lymphocyte trafficking

    1. Front Matter
      Pages 5-5
    2. Gao Ping, Ji Ming Wang, O. M. Zack Howard, Joost J. Oppenheim
      Pages 7-38
    3. Gabriela Constantin, Carlo Laudanna
      Pages 39-54
    4. Silvano Sozzani, Annalisa Del Prete, Karel Otero, Amerigo Santoro, William Vermi, Fabio Facchetti
      Pages 71-93
    5. Angela Gismondi, Angela Santoni
      Pages 95-112
  4. Immunopathology of lymphocyte trafficking

    1. Front Matter
      Pages 113-113
    2. Nicholas W. Lukacs, Matthew Schaller
      Pages 115-131
    3. Ineke M. Dijkstra, Richard M. Ransohoff
      Pages 133-149
    4. Takashi Wada, Hitoshi Yokoyama, Shuichi Kaneko, Kouji Matsushima
      Pages 151-165
    5. Nadia Giarratana, Giuseppe Penna, Susana Amuchastegui, Roberto Mariani, Luciano Adorini
      Pages 167-179
    6. Christopher A. Haskell, Richard Horuk
      Pages 181-196
  5. Inherited disorders of lymphocyte trafficking

    1. Front Matter
      Pages 197-197
    2. Amos Etzioni
      Pages 199-210
    3. Gerben Bouma, Adrian J. Thrasher, Siobhan Burns
      Pages 211-231
    4. Raffaele Badolato, Vanessa Bonomi, Laura Tassone
      Pages 233-242
  6. Back Matter
    Pages 243-249

About this book


Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.


Chemokine NK cells T cell biology cell cytoskeleton immune response immune system immunology inflammation migration mutation pathogenesis physiology skeleton

Editors and affiliations

  • Raffaele Badolato
    • 1
  • Silvano Sozzani
    • 2
  1. 1.Department of PediatricsUniversity of BresciaBresciaItaly
  2. 2.Section of General Pathology and ImmunologyUniversity of BresciaBresciaItaly

Bibliographic information

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Health & Hospitals