Chemokine Biology — Basic Research and Clinical Application

Volume I: Immunobiology of Chemokines

  • Bernhard Moser
  • Gordon L. Letts
  • Kuldeep Neote

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Marco Baggiolini
      Pages 3-15
  3. Cellular targets in innate and adaptive immunity

    1. Front Matter
      Pages 17-17
    2. Charles R. Mackay, Bernhard Moser
      Pages 19-33
    3. William W. Agace, Bernhard Homey
      Pages 35-58
    4. Chenggang Jin, Craig T. Morita
      Pages 59-78
    5. Federica Sallusto, Alfonso Martín-Fontecha, Antonio Lanzavecchia
      Pages 79-89
    6. Mario Mellado, Carlos Martínez-A, José Miguel Rodríguez-Frade
      Pages 91-108
    7. Lixin Liu, Paul Kubes
      Pages 109-122
    8. Mariagrazia Uguccioni, Basil O. Gerber
      Pages 123-134
  4. Effector cell traffic-unrelated functions

    1. Front Matter
      Pages 135-135
    2. Ning Zhang, Joost J. Oppenheim
      Pages 137-150
    3. Alexandra Lucas, Dana McIvor, Grant McFadden
      Pages 165-182
    4. Paola Romagnani, Laura Lasagni, Sergio Romagnani
      Pages 183-203
  5. Back Matter
    Pages 205-210

About this book


The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.

This set of books* gives a state-of-the-art account of recent developments in this field in the form of summaries written by highly regarded experts. Volume I is focused on basic principles and progress in chemokine biology, and Volume II deals with issues related to chemokine-related drug development and potential therapeutic applications. These volumes provide both introductory and novel information for a broad readership, including clinicians and biomedical scientists.

*See also K. Neote/G.L. Letts/B. Moser, Chemokine Biology - Basic Research and Clinical Application. Volume II: Pathophysiology of Chemokines. 2006, Birkhäuser, Progress in Inflammation Research, ISBN 3-7643-7195-1.


Chemokine HIV biology cell immune response immunity immunobiology microorganisms migration opioid pathophysiology physiology research signal transduction tissue

Editors and affiliations

  • Bernhard Moser
    • 1
  • Gordon L. Letts
    • 2
  • Kuldeep Neote
    • 3
  1. 1.Institute of Cell BiologyUniversity of BernBernSwitzerland
  2. 2.NitroMed, Inc.BedfordUSA
  3. 3.Bone and InflammationEli Lilly and Company Lilly Corporate CenterIndianapolisUSA

Bibliographic information

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