© 2005

Sodium Channels, Pain, and Analgesia

  • Michael J. Parnham
  • Kevin Coward
  • Mark D. Baker


  • Written by well-known scientists in their respective fields

  • The Nav1.8 sodium channel is discussed

  • Provides current opinion and future direction


Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-x
  2. Joel A. Black, Bryan C. Hains, Sulayman D. Dib-Hajj, Stephen G. Waxman
    Pages 1-21
  3. Jennifer M.A Laird, Fernando Cervero, Jennifer M.A Laird
    Pages 63-70
  4. James A. Brock
    Pages 85-105
  5. Lodewijk V. Dekker, David Cronk
    Pages 123-143
  6. Andreas Scholz
    Pages 165-180
  7. Back Matter
    Pages 195-199

About this book


Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme.

Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.


Nervous System Sodium channels analgesics brain drug gene membrane neurons pain protein proteins research tissue transcription treatment

Editors and affiliations

  • Michael J. Parnham
    • 1
  • Kevin Coward
    • 2
  • Mark D. Baker
    • 3
  1. 1.PLIVA Research Institute Ltd.ZagrebCroatia
  2. 2.Department of PharmacologyUniversity of OxfordOxfordUK
  3. 3.Molecular Nociception Group Department of Biology Medawar BuildingUniversity College LondonLondonUK

Bibliographic information

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