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Biosynthesis

Polyketides and Vitamins

  • Finian J. Leeper
  • John C. Vederas

Part of the Topics in Current Chemistry book series (volume 195)

Table of contents

  1. Front Matter
    Pages I-X
  2. James Staunton, Barrie Wilkinson
    Pages 49-92
  3. Tadhg P. Begley, Cynthia Kinsland, Sean Taylor, Manish Tandon, Robb Nicewonger, Min Wu et al.
    Pages 93-142
  4. Alan R. Battersby, Finian J. Leeper
    Pages 143-193
  5. Back Matter
    Pages 195-205

About this book

Introduction

The present volume is the first of two planned to provide state-of-the-art expert reviews of central topics in modern natural products chemistry and secondary metabolism. Many scientists not directly involved in these areas still view the field of natural products as focused primarily on the isolation,structure elucidation, and cataloging of new compounds (i. e. “grind and find”),or on their chemical synthesis. However,two revolutions in experimental techniques since the early 1950’s have completely transformed the understanding of chemical and biological relationships between highly diverse natural products. The first was the use isotopes to label precursors and follow the fate of key atoms during biochemical transformations to a final product. Advances in methodology that began in the mid-1970’s,especially using NMR to detect stable isotopes,dramatically expanded the level of mechanistic detail available to study in vivo conversions of secondary metabolites. The second revolution started in the late 1980’s as researchers developed methods to identify,purify and genetically manipulate individual enzymes - sponsible for the intricate steps leading to complex natural products. This has expanded the field from building an encyclopaedia of natural materials to being able to initiate control of biochemical pathways to secondary metabolites. Recent advances suggest it may soon be possible to rationally manipulate biochemical pathways in vivo to rapidly produce almost any target molecule,including n- natural variants,in substantial quantity.

Keywords

Biosynthese Expression Isotope Sekundärmetabolite Vitamine bioorganic chemistry biosynthesis chemistry cloning enzyme enzymes isotopes natural product organic chemistry synthesis

Editors and affiliations

  • Finian J. Leeper
    • 1
  • John C. Vederas
    • 2
  1. 1.Department of ChemistryUniversity of CambridgeCambridgeGreat Britain
  2. 2.Department of ChemistryUniversity of AlbertaEdmontonCanada

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-69542-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-63418-8
  • Online ISBN 978-3-540-69542-4
  • Series Print ISSN 0340-1022
  • Buy this book on publisher's site
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