Cross-Coupling Reactions

A Practical Guide

  • Norio Miyaura

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 219)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Kohei Tamao, Norio Miyaura
    Pages 1-9
  3. Norio Miyaura
    Pages 11-59
  4. Tamejiro Hiyama, Eiji Shirakawa
    Pages 61-85
  5. Keigo Fugami, Masanori Kosugi
    Pages 87-130
  6. Alex R. Muci, Stephen L. Buchwald
    Pages 131-209
  7. Masahiro Miura, Masakatsu Nomura
    Pages 211-241
  8. Back Matter
    Pages 243-248

About this book


In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).


Coupling reaction Material Science Materialwissenschaft Metallorganische Chemie Organometallic Chemistry Physical Chemistry Physikalische Chemie chemistry materials science

Editors and affiliations

  • Norio Miyaura
    • 1
  1. 1.Division of Molecular Chemistry Graduate School of EngineeringHokkaido UniversitySapporoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-42175-7
  • Online ISBN 978-3-540-45313-0
  • Series Print ISSN 0340-1022
  • Buy this book on publisher's site
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