Table of contents

  1. Front Matter
    Pages I-IX
  2. J. Liu, D. Levens
    Pages 1-32
  3. M. D. Cole, M. A. Nikiforov
    Pages 33-50
  4. D. Kleine-Kohlbrecher, S. Adhikary, M. Eilers
    Pages 51-62
  5. L. A. Lee, C. V. Dang
    Pages 145-167
  6. M. Pirity, J. K. Blanck, N. Schreiber-Agus
    Pages 205-234
  7. Back Matter
    Pages 279-282

About this book


Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.


apoptosis cellular transformation growth invertebrates metabolism nuclear proteins proliferation protein proteins signal transduction transcription transcriptional regulation

Editors and affiliations

  • R. N. Eisenman
    • 1
  1. 1.Division of Basic SciencesFred Hutchinson Cancer Research CenterSeattleUSA

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