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Axonal Branching and Recovery of Coordinated Muscle Activity after Transection of the Facial Nerve in Adult Rats

  • Doychin N. Angelov
  • Wolfram F. Neiss
  • Orlando Guntinas-Lichius
  • Michael Streppel
  • Konstantin Wewetzer
Book

Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 180)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Pages 37-91
  3. Pages 91-108
  4. Pages 108-108
  5. Back Matter
    Pages 109-131

About this book

Introduction

Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets, which consists of two major components. First, due to malfunctioning axonal guidance, a muscle gets reinnervated by a "foreign" axon, that has been misrouted along a "wrong" fascicle. Second, the supernumerary collateral branches emerging from all transected axons simultaneously innervate antagonistic muscles and cause severe impairment of their coordinated activity. Since it is hardly possible to influence the first major component and improve the guidance of several thousands axons, the authors concentrated on the second major component and tried to reduce the collateral axonal branching.

Keywords

autologous olfactory mucosa axonal regrowth cytoskeleton facial pareses influence muscle neuronal regeneration peripheral nerve regeneration regeneration

Authors and affiliations

  • Doychin N. Angelov
    • 1
  • Wolfram F. Neiss
    • 1
  • Orlando Guntinas-Lichius
    • 2
  • Michael Streppel
    • 2
  • Konstantin Wewetzer
    • 3
  1. 1.Institut I für AnatomieUniversität zu KölnKölnGermany
  2. 2.Klinik für Hals-, Nasen- und OhrenheilkundeUniversität zu KölnKölnGermany
  3. 3.Department of PathologyHannover Veterinary SchoolHannoverGermany

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