Current Concepts in Autoimmunity and Chronic Inflammation

  • Andreas Radbruch
  • Peter E. Lipsky

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 305)

Table of contents

  1. Front Matter
    Pages I-IX
  2. F. Melchers, A. R. Rolink
    Pages 1-23
  3. J. F. G. Cohen-Solal, V. Jeganathan, C. M. Grimaldi, E. Peeva, B. Diamond
    Pages 67-88
  4. M. Recher, K. S. Lang
    Pages 89-104
  5. D. J. B. Marks, N. A. Mitchison, A. W. Segal, J. Sieper
    Pages 105-125
  6. U. S. Gaipl, A. Sheriff, S. Franz, L. E. Munoz, R. E. Voll, J. R. Kalden et al.
    Pages 161-176
  7. A. Skapenko, P. E. Lipsky, H. Schulze-Koops
    Pages 195-211
  8. T. Dörner, P. E. Lipsky
    Pages 213-240
  9. R. A. Manz, K. Moser, G. -R. Burmester, A. Radbruch, F. Hiepe
    Pages 241-257
  10. M. Johannesson, M. Hultqvist, R. Holmdahl
    Pages 259-276
  11. Back Matter
    Pages 277-282

About this book


The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.


T cell apoptosis autoimmune disease autoimmunity cell cytokine diseases genes genetics infection macrophages necrosis pathology self-tolerance sex

Editors and affiliations

  • Andreas Radbruch
    • 1
  • Peter E. Lipsky
    • 2
  1. 1.Deutsches Rheumaforschungszentrum Berlin (DRFZ)BerlinGermany
  2. 2.National Institute of Arthritis and Musculoskeletal and Skin DiseasesBethesdaUSA

Bibliographic information

Industry Sectors
Health & Hospitals