Advertisement

Regulation of Sertoli Cell and Germ Cell Differentation

  • Ralph Brehm
  • Klaus Steger
  • F. F. Beck
  • B. Christ
  • F. Clascá
  • D. E. Haines
  • H.-W. Korf
  • W. Kummer
  • E. Marani
  • R. Putz
  • Y. Sano
  • T.H. Schiebler
  • K. Zilles
Book

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 181)

Table of contents

About this book

Introduction

Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.

Keywords

germ cell tumor haploid spermatids infertility male infertility spermatogenesis spermatogonial stem cells testicular disorders

Authors and affiliations

  • Ralph Brehm
    • 1
  • Klaus Steger
    • 2
  1. 1.Institut für Veterinär-Anatomie, Histologie und EmbryologieJustus-Liebig UniverstätGiessenGermany
  2. 2.Klinik und Poliklinik für Urologie und KinderurologieJustus-Liebig UniverstätGiessenGermany

Editors and affiliations

  • F. F. Beck
    • 1
  • B. Christ
    • 2
  • F. Clascá
    • 3
  • D. E. Haines
    • 4
  • H.-W. Korf
    • 5
  • W. Kummer
    • 6
  • E. Marani
    • 7
  • R. Putz
    • 8
  • Y. Sano
    • 9
  • T.H. Schiebler
    • 10
  • K. Zilles
    • 11
  1. 1.Melbourne
  2. 2.Freiburg
  3. 3.Madrid
  4. 4.Jackson
  5. 5.Frankfurt
  6. 6.Giessen
  7. 7.Leiden
  8. 8.München
  9. 9.Kyoto
  10. 10.Würzburg
  11. 11.Düsseldorf

Bibliographic information

Industry Sectors
Biomedicine
Pharma
Health & Hospitals
Biotechnology
Consumer Packaged Goods