© 2007

Systems Biology

  • Mohamed Al-Rubeai
  • Martin Fussenegger

Part of the Cell Engineering book series (CEEN, volume 5)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Kenneth Lundstrom
    Pages 1-27
  3. Maria Thomas, Natalia Martínez Soria, Olaf Heidenreich
    Pages 29-48
  4. Peter Morin Nissom, Robin Philp
    Pages 49-68
  5. Natalie Strudwick, Martin Schröder
    Pages 69-155
  6. Vasiliki Ifandi, Mohamed Al-Rubeai
    Pages 157-183
  7. Sarah J Scott, Rosalyn J Marchant, Mohamed B Al-Fageeh, Michèle F Underhill, C Mark Smales
    Pages 185-212
  8. Susan T. Sharfstein, Duan Shen, Thomas R. Kiehl, Rui Zhou
    Pages 213-236
  9. Soo Hean Gary Khoo, Mohamed Al-Rubeai
    Pages 237-273
  10. D.E. Martens
    Pages 275-299
  11. Effendi Leonard, Zachary L. Fowler, Mattheos Koffas
    Pages 301-359
  12. Peter Dittrich, Pietro Speroni Di Fenizio
    Pages 361-393
  13. Amy K. Schmid, Nitin S. Baliga
    Pages 395-423

About this book


A comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as RNAi, metabolic engineering and unfolded protein response. It includes reviews of the cellular response of environmental modulation such as low temperature and osmolarity, critical assessments of the applications of metabolomics and fluxomics approaches, examination of the utility of modulation of key genes and a presentation of a theory of chemical organisation which provides a new view of the system's structure. The clearly written chapters by experts in the field describe methods applicable to investigating the unique facets of cell culture. The book should be of interest to all those working in cell culture development and drug discovery in pharmaceutical and biotechnology companies as well as in academic institutions. It provides an invaluable resource for students and researchers in biotechnology, cell culture, genomics and bioinformatics.


Cell Engineering de Castro Proteomics RNA bioinformatics biology genes genome membrane proteins

Editors and affiliations

  • Mohamed Al-Rubeai
    • 1
  • Martin Fussenegger
    • 2
  1. 1.University College DublinIreland
  2. 2.Swiss Federal Institute of TechnologyETH Hoenggeerberg HCI Institute of Chemical and Bioengineering ICBZurichSwitzerland

Bibliographic information

Industry Sectors


From the reviews:

"This book is written for basic science and clinical researchers … . Biomedical scientists involved in genomics/proteomics research and drug discovery will also appreciate the wealth of information and interesting new concepts presented. … The chapters are well written and the topics are interesting. … the book is intended both for advanced students and experts in theoretical systems biology. … The authors illustrate their work nicely and provide general readers with a vision of future developments expected in cellular engineering." (Bruce A. Fenderson, Doody’s Review Service, August, 2008)