Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs)

A New Potential Strategy in Cancer Therapy

  • A-Majid Khatib

Table of contents

  1. Front Matter
    Pages I-5
  2. Abdel-Majid Khatib, Nathalie Scamuffa, Fabien Calvo, Michel Chrètien, Nabil G. Seidah
    Pages 7-26
  3. Stephanie McMahon, Claire M. Dubois
    Pages 27-45
  4. Brigitte L. Thèriault, Yangxin Fu, Shawn K. Murray, Mark W. Nachtigal
    Pages 47-65
  5. Geraldine Siegfried, Michel Chrètien, Abdel-Majid Khatib
    Pages 67-88
  6. Daniel E. Bassi, Andrès J.P. Klein-Szanto
    Pages 89-106
  7. Abdel-Majid Khatib, Siegfried Geraldine
    Pages 121-135
  8. Ajoy Basak, Upendra K. Banik, Sarmistha Basak, Nabil G. Seidah, Suiyang Li
    Pages 137-154
  9. Back Matter

About this book


Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting.

The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.


Prosegments angiogenesis carcinogenesis cell convertases enzymes metastasis ovarian cancer processing tumor tumor progression tumorigenesis

Editors and affiliations

  • A-Majid Khatib
    • 1
  1. 1.INSERMParis

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods