© 2005

Genome Instability in Cancer Development

  • Nathan Back
  • Irun R. Cohen
  • David Kritchevsky
  • Abel Lajtha
  • Rodolfo Paoletti
  • Erich A. Nigg
  • A focus on genome instability – a hallmark of human cancer

  • An in-depth discussion of the causes and consequences of genome instability

  • A molecular analysis of one of the most fundamental traits of human cancers

  • A compilation of authoritative reviews from leading researchers


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 570)

Table of contents

  1. Front Matter
    Pages i-xv
  2. The Problem of Genome Instability

    1. Ranga N. Venkatesan, Lawrence A. Loeb
      Pages 3-17
    2. Michael R. Speicher
      Pages 19-41
  3. DNA Repair and Mutagenesis

    1. Jaan-Olle Andressoo, Jan H.J. Hoeijmakers, Harm de Waard
      Pages 45-83
    2. Giancarlo Marra, Josef Jiricny
      Pages 85-123
    3. Lisiane B. Meira, Nicholas E. Burgis, Leona D. Samson
      Pages 125-173
    4. Penny A. Jeggo
      Pages 175-197
    5. Catherine M. Green, Alan R. Lehmann
      Pages 199-223
  4. Cell Cycle Progression and Chromosome Aberration

    1. Ana del Gutierrez Arroyo, Gordon Peters
      Pages 227-247
    2. Wenge Zhu, Tarek Abbas, Anindya Dutta
      Pages 249-279
    3. Tomohiro Matsumoto, Mitsuhiro Yanagida
      Pages 281-310
    4. Roger A. Greenberg, K. Lenhard Rudolph
      Pages 311-341
    5. Michelle Debatisse, Bernard Malfoy
      Pages 343-361
    6. Wilma L. Lingle, Kara Lukasiewicz, Jeffrey L. Salisbury
      Pages 393-421
  5. Genome Integrity Checkpoints

    1. Zhenkun Lou, Junjie Chen
      Pages 425-455
    2. Martin F. Lavin, Sergei Kozlov, Nuri Gueven, Cheng Peng, Geoff Birrell, Phillip Chen et al.
      Pages 457-476
    3. Tim J. Yen, Gary D. Kao
      Pages 477-499
  6. Back Matter
    Pages 501-511

About this book


Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.


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Editors and affiliations

  • Nathan Back
    • 2
  • Irun R. Cohen
    • 3
  • David Kritchevsky
    • 4
  • Abel Lajtha
    • 5
  • Rodolfo Paoletti
    • 6
  • Erich A. Nigg
    • 1
  1. 1.Max-Planck Institute of BiochemistryMartinsriedGermany
  2. 2.State University of New YorkBuffalo
  3. 3.The Weizmann Institute of ScienceIsrael
  4. 4.Wistar InstituteUSA
  5. 5.N. S. Kline Institute for Psychiatric ResearchUSA
  6. 6.University of MilanItaly

Bibliographic information

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