© 2006

Tight Junctions


Table of contents

  1. Front Matter
    Pages i-xiii
  2. Marcelino Cereijido, María del Refugio García-Villegas, Liora Shoshani, Ruben Gerardo Contreras
    Pages 1-18
  3. Yan-Hua Chen, Daniel A. Goodenough, Qun Lu
    Pages 19-32
  4. James Melvin Anderson, Christina M. Van Itallie
    Pages 33-42
  5. Susumu Hirabayashi, Yutaka Hata
    Pages 43-53
  6. Laurent Guillemot, Sandra Citi
    Pages 54-63
  7. Alan S. Fanning
    Pages 64-75
  8. Esther Lopez-Bayghen, Blanca Estela Jaramillo, Miriam Huerta, Abigail Betanzos, Lorenza Gonzalez-Mariscal
    Pages 76-100
  9. Emma Kavanagh, Anna Tsapara, Karl Matter, Maria S. Balda
    Pages 101-115
  10. Isabel J. Latorre, Kristopher K. Frese, Ronald T. Javier
    Pages 116-134
  11. Liora Shoshani, David Flores-BenÍtez, Lorenza Gonzalez-Mariscal, Rubén Gerardo Contreras
    Pages 146-163
  12. Bhavwanti Sheth, Judith Eckert, Fay Thomas, Tom P. Fleming
    Pages 164-174
  13. Hartwig Wolburg, Andrea Lippoldt, Klaus Ebnet
    Pages 175-195
  14. Jeff M. Bronstein, Seema Tiwari-Woodruff
    Pages 196-205
  15. Noha N. Salama, Natalie D. Eddington, Alessio Fasano
    Pages 206-219
  16. Back Matter
    Pages 221-224

About this book


ight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol­ ogy and function in response to physiological, pharmacological and pathologi­ cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec­ tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand­ ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.


Evolution Nervous System Regulation gene expression genes phenotype proteins

Authors and affiliations

  1. 1.Department of Physiology, Biophysics and NeuroscienceCenter for Research and Advanced Studies (CINVESTAV)México D.F.México

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