Principles of Protein X-Ray Crystallography

  • Jan Drenth

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Jan Drenth
    Pages 1-20
  3. Jan Drenth
    Pages 21-44
  4. Jan Drenth
    Pages 45-63
  5. Jan Drenth
    Pages 119-122
  6. Jan Drenth
    Pages 172-193
  7. Jan Drenth
    Pages 210-230
  8. Jan Drenth
    Pages 231-240
  9. Jan Drenth
    Pages 241-247
  10. Jan Drenth
    Pages 248-278
  11. Jan Drenth
    Pages 279-284
  12. Jeroen R. Mesters
    Pages 297-304
  13. Back Matter
    Pages 305-332

About this book


X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, Dr. Jan Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided an up-to-date and technically rigorous introduction to the subject.

Principles of Protein X-ray Crystallography provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to serve as an introduction for graduate students, postdoctoral researchers, and established scientists who want to use protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. New additions to the book include a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion (SAD).


"The new edition... will bring important and significant, and timely, coverage of twinning and of SAD phasing." – Professor John Helliwell, Department of Chemistry, University of Manchester

"a complete and up to date... single source of theory." – Duncan McRee, President, ActiveSight

About the Authors:

Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands.

Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany.


Biophysics Crystallography SAD X-ray X-ray diffraction biochemistry crystal growth crystal twinning protein proteins scattering single-wavelength anomalous dispersion

Authors and affiliations

  • Jan Drenth
    • 1
  1. 1.Laboratory of Biophysical ChemistryUniversity of GroningenGroningenThe Netherlands

Bibliographic information

Industry Sectors
Chemical Manufacturing
Health & Hospitals
Consumer Packaged Goods