Modeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics

Homogeneous and Heterogeneous Approaches

  • Panos Macheras
  • Athanassios Iliadis

Part of the Interdisciplinary Applied Mathematics book series (IAM, volume 30)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Basic Concepts

    1. Front Matter
      Pages 1-4
    2. Pages 39-51
  3. Modeling in Biopharmaceutics

    1. Front Matter
      Pages 53-55
    2. Pages 57-88
    3. Pages 89-112
    4. Pages 113-159
  4. Modeling in Pharmacokinetics

    1. Front Matter
      Pages 161-164
    2. Pages 165-182
  5. Modeling in Pharmacodynamics

    1. Front Matter
      Pages 289-292
  6. Back Matter
    Pages 353-442

About this book


The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.


absorption bioengineering drug dynamics kinetics pharmacodynamics pharmacokinetics pharmacology physiology research

Authors and affiliations

  • Panos Macheras
    • 1
  • Athanassios Iliadis
    • 2
  1. 1.School of PharmacyZographouGreece
  2. 2.Faculty of PharmacyMarseilles 13385 CXFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, Inc. 2006
  • Publisher Name Springer, New York, NY
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-0-387-28178-0
  • Online ISBN 978-0-387-31910-0
  • Series Print ISSN 0939-6047
  • Buy this book on publisher's site