© 2005



Part of the Medical Intelligence Unit book series (MIUN)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Renate Lüllmann-Rauch
    Pages 1-16
  3. Stephan Storch, Thomas Braulke
    Pages 17-26
  4. Paul Saftig
    Pages 37-49
  5. Klaudia Brix
    Pages 50-59
  6. Ole Kristian Greiner-Tollersrud, Thomas Berg
    Pages 60-73
  7. Frans W. Verheijen, Grazia M. S. Mancini
    Pages 74-81
  8. Jaana Tyynelä
    Pages 82-99
  9. Judith Storch, Sunita R. Cheruku
    Pages 100-111
  10. Ulrich Matzner
    Pages 112-129
  11. Jobst Landgrebe, Torben Lübke
    Pages 130-143
  12. Vincent Everts, Wouter Beertsen
    Pages 144-155
  13. Eeva-Liisa Eskelinen
    Pages 166-180
  14. Erwin Knecht, Natalia Salvador
    Pages 181-193
  15. Back Matter
    Pages 195-197

About this book


Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.


Chaperone Organelle Resorption enzymes proteins

Authors and affiliations

  1. 1.Biochemisches InstitutChristian-Albrechts-Universität KielKielGermany

Bibliographic information

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