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Expert diagnostic system for hemoglobinopathies using the data on blood, erythrocyte, and hemoglobin state

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Abstract

A conceptual model of the expert system (ES) of hemoglobinopathy diagnostics is considered. The ES core is the knowledge base (KB) including grouped data on qualitative and quantitative blood indicators, among which is the amount of membrane-bound hemoglobin, i.e., a new indicator in hematological practice. Quantitative indications are complemented by qualitative ones reflecting morphological changes of pathological erythrocytes. The presented ES is a tool for supporting doctor decision making in hemoglobinopathy diagnostics.

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Authors and Affiliations

  1. National Research Nuclear University “MEPhI”, Kashirskoe sh. 31, Moscow, 115409, Russia

    E. I. Nasybullina, V. G. Nikitaev & A. N. Pronichev

  2. A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia

    E. I. Nasybullina, O. V. Kosmachevskaya & A. F. Topunov

  3. N.N. Blokhin Russian Cancer Research Center, Kashirskoe sh. 23, Moscow, 115478, Russia

    V. N. Blindar

Authors
  1. E. I. Nasybullina
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  2. V. G. Nikitaev
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  3. A. N. Pronichev
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  4. V. N. Blindar
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  5. O. V. Kosmachevskaya
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  6. A. F. Topunov
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Corresponding author

Correspondence to V. N. Blindar.

Additional information

Original Russian Text © E.I. Nasybullina, V.G. Nikitaev, A.N. Pronichev, V.N. Blindar, O.V. Kosmachevskaya, A.F. Topunov, 2015, published in Kratkie Soobshcheniya po Fizike, 2015, Vol. 42, No. 7, pp. 22–27.

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Nasybullina, E.I., Nikitaev, V.G., Pronichev, A.N. et al. Expert diagnostic system for hemoglobinopathies using the data on blood, erythrocyte, and hemoglobin state. Bull. Lebedev Phys. Inst. 42, 206–208 (2015). https://doi.org/10.3103/S1068335615070039

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  • DOI: https://doi.org/10.3103/S1068335615070039

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