Moscow University Chemistry Bulletin

, Volume 72, Issue 6, pp 328–332 | Cite as

Determination of Codeine Phosphate in the Culture Fluid of Rhodococcus by High-Performance Liquid Chromatography

  • A. N. Plotnikov
  • Yu. N. Karpenko
  • E. V. Vikhareva
  • E. A. Tyumina
  • M. I. Richkova
  • A. A. Selyaninov


The conditions for the quantitative determination of codeine phosphate in the culture fluid of Rhodococcus by reversed-phase high-performance liquid chromatography (RP-HPLC) are established. The specificity, linearity, precision, and accuracy of the method are confirmed by the validation procedure.


codeine phosphate biological degradation Rhodococci reversed-phase high-performance liquid chromatography 


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Copyright information

© Allerton Press, Inc. 2017

Authors and Affiliations

  • A. N. Plotnikov
    • 1
  • Yu. N. Karpenko
    • 1
  • E. V. Vikhareva
    • 1
  • E. A. Tyumina
    • 2
  • M. I. Richkova
    • 3
  • A. A. Selyaninov
    • 4
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Perm State National Research UniversityPermRussia
  3. 3.Institute of Ecology and Genetics of Microorganisms, Ural BranchRussian Academy of SciencesPermRussia
  4. 4.Perm National Research Polytechnic UniversityPermRussia

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