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Moscow University Chemistry Bulletin

, Volume 72, Issue 6, pp 322–324 | Cite as

Development and Validation of the Quantification of GML-1 Compound (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-A] pyrazine- 3-carbamide) in the Blood Plasma of Rats by HPLC–MS

  • A. A. Novitskiy
  • P. O. Bochkov
  • A. A. Litvin
  • V. P. Zherdev
  • E. V. Blynskaya
Article
  • 5 Downloads

Abstract

The technique of quantitative determination of a new compound, possessing anxiolytic activity, GML-1 in the blood plasma of rats is developed and validated. The analysis is performed by HPLC–MS. The method is linear in the range of 50–1000 ng/mL. 83.63% of GML-1 was recovered. The detection limit was 25 ng/mL.

Keywords

GML-1 blood plasma HPLC–MS quantification 

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References

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Copyright information

© Allerton Press, Inc. 2017

Authors and Affiliations

  • A. A. Novitskiy
    • 1
  • P. O. Bochkov
    • 1
  • A. A. Litvin
    • 1
  • V. P. Zherdev
    • 1
  • E. V. Blynskaya
    • 1
  1. 1.Zakusov Institute of PharmacologyMoscowRussia

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