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Development and Validation of the Quantification of GML-1 Compound (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-A] pyrazine- 3-carbamide) in the Blood Plasma of Rats by HPLC–MS

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Abstract

The technique of quantitative determination of a new compound, possessing anxiolytic activity, GML-1 in the blood plasma of rats is developed and validated. The analysis is performed by HPLC–MS. The method is linear in the range of 50–1000 ng/mL. 83.63% of GML-1 was recovered. The detection limit was 25 ng/mL.

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Authors and Affiliations

  1. Zakusov Institute of Pharmacology, Moscow, 125315, Russia

    A. A. Novitskiy, P. O. Bochkov, A. A. Litvin, V. P. Zherdev & E. V. Blynskaya

Authors
  1. A. A. Novitskiy
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  2. P. O. Bochkov
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  3. A. A. Litvin
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  4. V. P. Zherdev
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  5. E. V. Blynskaya
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Corresponding author

Correspondence to A. A. Novitskiy.

Additional information

Original Russian Text © A.A. Novitskiy, P.O. Bochkov, A.A. Litvin, V.P. Zherdev, E.V. Blynskaya, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 1, pp. 43–45.

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Novitskiy, A.A., Bochkov, P.O., Litvin, A.A. et al. Development and Validation of the Quantification of GML-1 Compound (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-A] pyrazine- 3-carbamide) in the Blood Plasma of Rats by HPLC–MS. Moscow Univ. Chem. Bull. 72, 322–324 (2017). https://doi.org/10.3103/S0027131418010042

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  • DOI: https://doi.org/10.3103/S0027131418010042

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