Moscow University Chemistry Bulletin

, Volume 72, Issue 6, pp 260–266 | Cite as

Kinetics of Extraction of Biologically Active Substances from Medicinal Plant Raw Materials using Different Techniques

  • V. V. Milevskaya
  • T. S. Butylskaya
  • Z. A. Temerdashev
  • M. A. Statkus
  • N. V. Kiseleva
Article
  • 3 Downloads

Abstract

The problems and peculiarities of obtaining the kinetic characteristics of extraction of biologically active substances (BAS) from a plant matrix are discussed. The establishment of kinetic characteristics of the extraction of BAS under various extraction conditions is studied on the example of samples of Hypericum perforatum and Salvia officinalis. The lowest value of the average rate constant of the extraction of BAS from the materials examined is characteristic of a variant of static extraction with an aqueous alcohol extractant under heating. The methods of static extraction under heating (according to the requirements of pharmacopoeia articles) and ultrasonication, as well as using double ultrasonication differ little from each other in their kinetic efficiency. The method of dynamic extraction of BAS at an elevated temperature and pressure is characterized by the highest values of the rate constant, which leads to an acceleration of the diffusion of the BAS into the extractant’s medium. It is noted that the extraction processes and chemical transformations of some BAS (hyperforin, carnosic acid, etc.) occur simultaneously as confirmed by the decrease in their concentrations in the extractant during the extraction from plant samples.

Keywords

extraction kinetics biologically active substances Hypericum perforatum Salvia officinalis 

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References

  1. 1.
    Kruglov, D.S., Farm. Nauki, 2015, no. 2, p. 4693.Google Scholar
  2. 2.
    WHO Monographs on Selected Medicinal Plants, 2009, vol. 4, p.456.Google Scholar
  3. 3.
    Traditional Herbal Medicine Research Methods: Identification, Analysis, Bioassay, and Pharmaceutical and Clinical Studies, Liu, W.J.H., Ed., Hoboken, NJ: Wiley, 2011.Google Scholar
  4. 4.
    Ponomarev, V.D., Ekstragirovanie lekarstvennogo syr’ya (Extraction of Medicinal Raw Materials), Moscow: Meditsina, 1976.Google Scholar
  5. 5.
    Myasnikov, V.Yu., Ivanov, E.V., and Sakanyan, E.I., Pharm. Chem. J., 2010, vol. 44, no. 4, p.38.CrossRefGoogle Scholar
  6. 6.
    Cavdarova, M. and Makri, D.P., Waste Biomass Valorization, 2014, vol. 5, no. 5, p.773.CrossRefGoogle Scholar
  7. 7.
    Kadam, S.U. Tiwari, B.K., O’Connell, S., and O’Donnell, C.P., Sep. Sci. Technol., 2015, vol. 50, no. 5, p.670.CrossRefGoogle Scholar
  8. 8.
    Torun, M., Dincer, C., Topuz, A., Sahin-Nadeem, H., and Ozdemir, F., J. Food Sci. Technol., 2015, vol. 52, no. 5, p. 2797.CrossRefGoogle Scholar
  9. 9.
    Herodez, S.S., Hadolin, M., Skerget, M., and Knez, Z., Food Chem., 2003, vol. 80, p.275.CrossRefGoogle Scholar
  10. 10.
    Malkov, Yu.A., Ivanova, N.V., and Babkin, V.A., Khim. Rastit. Syr’ya, 2012, no. 2, p.63.Google Scholar
  11. 11.
    Paunovica, D.D., Mitica, S.S., Stojanovica, G.S., Mitic, M.N., Stojanovic, B.T., and Stojkovic, M.B., Sep. Sci. Technol., 2015, vol. 50, no. 11, p. 1658.CrossRefGoogle Scholar
  12. 12.
    Balyan, U. and Sarkar, B., Int. J. Food Prop., 2017, vol. 20, no. 2, p.372.CrossRefGoogle Scholar
  13. 13.
    Velickovic, D.T., Milenovic, D.M., Ristic, M.S., and Veljkovic, V.B., Ultrason. Sonochem., 2006, vol. 13, p.150.CrossRefGoogle Scholar
  14. 14.
    Herodez, S.S., Hadolin, M., Skerget, M., and Knez, Z., Food Chem., 2003, vol. 80, p.275.CrossRefGoogle Scholar
  15. 15.
    Yang, Y.-C. and Wei, M.-C., Food Bioprod. Process., 2015, vol. 94, p.101.CrossRefGoogle Scholar
  16. 16.
    Qu, W., Pan, Z., and Ma, H., J. Food Eng., 2010, vol. 99, no. 1, p.16.CrossRefGoogle Scholar
  17. 17.
    Yang, Y.-C., Wei, M.-C., and Hong, S.-J., J. Chromatogr. A, 2014, vol. 1323, p.18.CrossRefGoogle Scholar
  18. 18.
    Wei, M.-C. and Yang, Y.-C., Sep. Purif. Technol., 2014, vol. 130, p.182.CrossRefGoogle Scholar
  19. 19.
    Pan, Z., Qu, W., Ma, H., Atungulu, G.G., and McHugh, T.H., Ultrason. Sonochem., 2011, vol. 18, p. 1249.CrossRefGoogle Scholar
  20. 20.
    Xi, J. and Luo, S., Sep. Purif. Technol., 2015, vol. 156, p.809.CrossRefGoogle Scholar
  21. 21.
    Schwarz, K. and Ternes, W., Z. Lebensm.-Unters. Forsch., 1992, no. 195, p.99.CrossRefGoogle Scholar
  22. 22.
    Milevskaya, V.V., Statkus, M.A., Temerdashev, Z.A., Kiseleva, N.V., and Vernikovskaya, N.A., J. Anal. Chem., 2015, vol. 70, no. 12, p. 1432.CrossRefGoogle Scholar
  23. 23.
    Milevskaya, V.V., Statkus, M.A., Temerdashev, Z.A., Kiseleva, N.V., Butyl’skaya, T.S., and Shil’ko, E.A., J. Anal. Chem., 2016, vol. 71, no. 7, p.741.CrossRefGoogle Scholar
  24. 24.
    Gosudarstvennaya Farmakopeya RF (Russian State Pharmacopoeia), Moscow, 2015, vol.1.Google Scholar
  25. 25.
    Verotta, L., Lovaglio, E., Sterner, O., Appendino, G., and Bombardelli, E., Org. Chem., 2004, no. 69, p. 7869.CrossRefGoogle Scholar
  26. 26.
    Cuvelier, M.-E., Berset, C., and Richard, H., J. Agric. Food Chem., 1994, no. 42, p.665.CrossRefGoogle Scholar
  27. 27.
    Birtic, S., Dussort, P., Pierre, F.-X., Bily, A.C., and Roller, M., Phytochemistry, 2015, no. 115, p.9.CrossRefGoogle Scholar
  28. 28.
    Sovova, H., J. Supercrit. Fluids, 2005, vol. 33, p.35.CrossRefGoogle Scholar
  29. 29.
    Harouna-Oumarou, H.A., Fauduet, H., Porte, C., and Ho, Y.-S., Chem. Eng. Commun., 2007, no. 194, p.537.CrossRefGoogle Scholar
  30. 30.
    Rogerio, A.P., Kanashiro, A., Fontanari, C., Silva, E.V.G., Lucisano-Valim, Y.M., Soares, E.G., and Faccioli, L.H., Inflammation Res., 2007, vol. 56, no. 10, p.402.CrossRefGoogle Scholar
  31. 31.
    Butterweck, V., Jurgenliemk, G., Nahrstedt, A., and Winterhoff, H., Planta Med., 2000, vol. 66, no. 1, p.3.CrossRefGoogle Scholar
  32. 32.
    Cervo, L., Rozio, M., Ekalle-Soppo, C.B., Guiso, G., Morazzoni, P., and Caccia, S., Psychopharmacology, 2002, vol. 164, p.423.CrossRefGoogle Scholar
  33. 33.
    Butterweck, V., Nahrstedt, A., Evans, J., Hufeisen, S., Rauser, L., Savage, J., Popadak, B., Ernsberger, P., and Roth, B.L., Psychopharmacology, 2002, vol. 162, no. 2, p.193.CrossRefGoogle Scholar
  34. 34.
    Obach, R.S., J. Pharmacol. Exp. Ther., 2000, vol. 294, no. 1, p.88.Google Scholar
  35. 35.
    Brockmoller, J., Reum, T., Bauer, S., Kerb, R., Hubner, W.-D., and Roots, I., Pharmacopsychiatry, 1997, vol. 30, p.94.CrossRefGoogle Scholar
  36. 36.
    Nakajima, Y., Shimazawa, M., Mishima, S., and Hara, H., Life Sci., 2007, vol. 80, no. 4, p.370.CrossRefGoogle Scholar
  37. 37.
    Aruoma, O., Halliwell, B., Aeschbach, R., and Loligers, J., Chem. Unserer Zeit, 1992, vol. 22, no. 2, p. 257.Google Scholar

Copyright information

© Allerton Press, Inc. 2017

Authors and Affiliations

  • V. V. Milevskaya
    • 1
  • T. S. Butylskaya
    • 1
  • Z. A. Temerdashev
    • 1
  • M. A. Statkus
    • 2
  • N. V. Kiseleva
    • 1
  1. 1.Kuban State UniversityKrasnodarRussia
  2. 2.Department of ChemistryMoscow State UniversityMoscowRussia

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