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Cryomodification of drugs: Micronized amorphous state of carvedilol

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Moscow University Chemistry Bulletin Aims and scope

Abstract

By means of cryochemical modification, including substance evaporation in a stream of a heated gas-carrier with subsequent condensation of vapor on a surface, cooled up to the boiling temperature of liquid nitrogen (−196°C), the X-ray amorphous state of the drug carvedilol, (±)-1-(9H-carbazole-4-iloxy)-3-[2-(2-methoxyphenoxy)-ethylamino]propane-2-ol, was obtained. It is shown that, along with amorphization, cryomodification leads to micronization of the drug—the sizes of its particles decrease from an initial 5–10 up to 1–2 μm.

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Authors and Affiliations

  1. Department of Chemical Kinetics, Moscow State University, Moscow, Russia

    B. M. Sergeev, S. P. Mikhalev, Yu. N. Morozov, V. P. Shabatin, P. N. Kolotilov & G. B. Sergeev

Authors
  1. B. M. Sergeev
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  2. S. P. Mikhalev
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  3. Yu. N. Morozov
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  4. V. P. Shabatin
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  5. P. N. Kolotilov
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  6. G. B. Sergeev
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Corresponding author

Correspondence to G. B. Sergeev.

Additional information

Original Russian Text © B.M. Sergeev, S.P. Mikhalev, Yu.N. Morozov, V.P. Shabatin, P.N. Kolotilov, G.B. Sergeev, 2010, published in Vestnik Moskovskogo Universiteta. Khimiya, 2010, No. 6, pp. 440–444.

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Sergeev, B.M., Mikhalev, S.P., Morozov, Y.N. et al. Cryomodification of drugs: Micronized amorphous state of carvedilol. Moscow Univ. Chem. Bull. 65, 366–369 (2010). https://doi.org/10.3103/S0027131410060064

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  • DOI: https://doi.org/10.3103/S0027131410060064

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