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Biomolecules in colloid nanocontainers for drug delivery: Entrapment and properties of the delta sleep-inducing peptide

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Moscow University Chemistry Bulletin Aims and scope

Abstract

Nanoemulsions of the water in oil type (w/o) composed of nontoxic components, including low concentrations of AOT (5%) and soy-bean lecithin Lipoid S100 (10%) in eucalyptus oil and limonene, were developed and characterized. These nanoemulsions can be used for the incorporation of biomolecules. As shown, AOT based systems possessed the highest solubilization capacity (12% of an aqueous solution); photon-correlation spectroscopy revealed that the size of nanoemulsions of 5% AOT in eucalyptus oil increased linearly with the growth of the water content. The ability of hydrophilic delta sleep-inducing peptide (DSIP), which is a regulatory neuropeptide, to exist in nanoemulsions of the w/o type in the absence and in the presence of additional biopolymers was demonstrated. DSIP entrapment in a nanoemulsion results in its substantial stabilization (80–90% after 2 months of incubation at 22°C versus 28% in an aqueous solution). The kinetics of peptide srelease was studied in in vitro model experiments; a substantial slowing-down of peptide release in nanoemulsions in comparison to aqueous solutions was revealed. DSIP-containing nanoemulsion systems, which can be used in medicine and cosmetology, can serve as a basis for the development of novel stable pharmaceutical dosage forms of prolonged action peptide preparations.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    T. V. Sukhanova, I. A. Prudchenko, E. S. Efremov & E. A. Markvicheva

  2. Department of Chemical Enzymology, Faculty of Chemistry, Moscow State University, Moscow, Russia

    S. V. Uglanova, L. Yu. Filatova & N. L. Klyachko

Authors
  1. T. V. Sukhanova
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  2. I. A. Prudchenko
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  3. E. S. Efremov
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  4. S. V. Uglanova
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  5. L. Yu. Filatova
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  6. E. A. Markvicheva
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  7. N. L. Klyachko
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Corresponding author

Correspondence to T. V. Sukhanova.

Additional information

Original Russian Text © T.V. Sukhanova, I.A. Prudchenko, E.S. Efremov, S.V. Uglanova, L.Yu. Filatova, E.A. Markvicheva, N.L. Klyachko, 2010, published in Vestnik Moskovskogo Universiteta. Khimiya, 2010, No. 3, pp. 209–214.

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Sukhanova, T.V., Prudchenko, I.A., Efremov, E.S. et al. Biomolecules in colloid nanocontainers for drug delivery: Entrapment and properties of the delta sleep-inducing peptide. Moscow Univ. Chem. Bull. 65, 175–179 (2010). https://doi.org/10.3103/S0027131410030132

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  • DOI: https://doi.org/10.3103/S0027131410030132

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