Advertisement

Surface Engineering and Applied Electrochemistry

, Volume 54, Issue 6, pp 607–613 | Cite as

The Development and Investigation of Biocompatibility Properties of Biodegradable Magnesium–Zinc Scaffold Electrodeposited with Hydroxyapatite

  • Z. S. SeyedraoufiEmail author
Article
  • 4 Downloads

Abstract

In the present work, a biodegradable porous Mg–3 wt % Zn scaffold was synthesized by a powder metallurgical method and then a nano hydroxyapatite (HAP) coating with the composition of Ca10(PO4)6(OH)2 on the scaffold was produced by pulse electrodeposition and alkali treatment processes to increase the biodegradability and biocompatibility of the scaffold. The results showed that the as-deposited coating consisted of HAP, CaHPO4 ⋅ 2H2O (DCPD) and Ca8H2(PO4)6 ⋅ 5H2O (OCP) with needle-like and plate-like morphologies; the post-treated coating was composed of a needle-like structure of nano HAP developed almost perpendicularly to the substrate. Electrochemical tests indicated that the corrosion current density reduced from 1.531 × 10–3 to 3.78 × 10–5 A cm–2 and the corrosion potential of the scaffold increased from–1.448 to–1.366 V. The results showed higher biocompatibility and cell viabilities for as-coated and post-treated scaffold extracts than that for an uncoated scaffold. Also, MG63 cells were found to adhere and proliferate on the surface of the as-coated and post-treated scaffolds, making it a promising choice for medical applications. This study showed that electrodeposition of a HAP coating is a useful approach to increase the corrosion resistance and biocompatibility of the porous Mg–Zn scaffold in simulated body fluid and to develop Mg-based scaffolds.

Keywords

porous scaffold Mg–Zn hydroxyapatite hiocompatibility electrodeposition 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yazdimamaghani, M., Razavi, M., Vashaee, D., Moharamzadeh, K., et al., Mater. Sci. Eng., C., 2017, vol. 71, pp. 1253–1266.CrossRefGoogle Scholar
  2. 2.
    Chang, C.H., Lin, F.H., Kuo, T.F. and Liu, H.C., Biomed. Eng.: Appl., Basis Commun., 2005, vol. 17, pp. 1–11.Google Scholar
  3. 3.
    Risbud, M.V. and Sittinger, M., Trends Biotechnol., 2000, vol. 20, no. 8, pp. 351–356.CrossRefGoogle Scholar
  4. 4.
    Bonadio, J., Smiley, E., Patil, P., and Goldstein, S., J. Nat. Med., 1999, vol. 5, no. 7, pp. 753–759.CrossRefGoogle Scholar
  5. 5.
    Cheung, H.Y., Lau, K.T., Lu, T.P. and Hui, D.A., Composites, Part B, 2007, vol. 38, pp. 291–300.CrossRefGoogle Scholar
  6. 6.
    Yusop, A.H., Bakir, A.A., Shaharom, N.A., Abdul Kadir, M.R., et al., Int. J. Biomater., 2012, vol. 10, pp. 1–10.CrossRefGoogle Scholar
  7. 7.
    Yazdimamaghani, M., Razavi, M., Vashaee, D., and Tayebi, L., Mater. Lett., 2014, 132, pp. 106–110.CrossRefGoogle Scholar
  8. 8.
    Saris, N.E.L., Mervaala, E., Karppanen, H., Khawaja, J.A., et al., Clin. Chim. Acta., 2000, vol. 294, nos. 1–2, pp. 1–26.CrossRefGoogle Scholar
  9. 9.
    Vormann, J., Mol. Aspects Med., 2003, vol. 24, nos. 1–3, pp. 27–37.CrossRefGoogle Scholar
  10. 10.
    Okuma, T., J. Nutr., 2001, vol. 17, nos. 7–8, pp. 679–680.CrossRefGoogle Scholar
  11. 11.
    Staiger, M.P., Pietak, A.M., Huadmai, J. and Dias, G., Biomaterials, 2006, vol. 27, no. 9, pp. 1728–1734.CrossRefGoogle Scholar
  12. 12.
    Dutta, S., Bavya Devi, K., and Roy, M., Adv. Powder Technol., 2017, vol. 28, no. 12, pp. 3204–3214. https://doi.org/10.1016/j.apt.2017.09.024 CrossRefGoogle Scholar
  13. 13.
    Witte, F., Kaese, V., Haferkamp, H., Switzer, E., et al., Biomaterials., 2005, vol. 26, no. 17, pp. 3557–3563.CrossRefGoogle Scholar
  14. 14.
    Zhang, X., Li, X.W., Li, J.G., and Sun, X.D., Mater. Sci. Eng., C, 2014, vol. 42, pp. 362–367.CrossRefGoogle Scholar
  15. 15.
    Yua, W., Zhaoa, H., Dinga, Zh., Zhanga, Zh., et al., Colloids Surf., B, 2017, vol. 149, pp. 330–340.CrossRefGoogle Scholar
  16. 16.
    Li, Z.J., Gu, X.N., Lou, S.Q., and Zheng, Y.F., Biomaterials., 2008, vol. 29, no. 10, pp. 1329–1344.CrossRefGoogle Scholar
  17. 17.
    Song, G.L., Corros. Sci., 2007, vol. 49, no. 4, pp. 1696–1701.CrossRefGoogle Scholar
  18. 18.
    Gonzáleza, S., Pellicera, E., Fornella, J., and Blanquer, A., J. Mech. Behav. Biomed., 2012, vol. 6, pp. 53–62.CrossRefGoogle Scholar
  19. 19.
    Khalil, K.A., Int. J. Electrochem. Sci., 2012, vol. 7, pp. 10698–10710.Google Scholar
  20. 20.
    Deng, C.J., Wong, M.L., Ho, M.W., Yu, P., and Dickon, H.L., Composites, Part A, 2005, vol. 36, no. 5, pp. 551–557.CrossRefGoogle Scholar
  21. 21.
    Gu, X., Zheng, Y., Zhong, S., and Xi, T., Biomaterials, 2010, vol. 31, no. 6, pp. 1093–1103.CrossRefGoogle Scholar
  22. 22.
    Kaya, A., Eliezer, D., Ben-Hamu, G., Golan, O., Na, Y.G., and Shin, K.S., Met. Sci. Heat Treat., 2003, vol. 48, pp. 50–54.Google Scholar
  23. 23.
    Zhang, E., Yin, D., Xu, L., Yang, L., and Yang, K., Mater. Sci. Eng., C, 2009, vol. 29, no. 3, pp. 987–993.CrossRefGoogle Scholar
  24. 24.
    Wang, H., Guan, S., Wang, X., Ren, C., and Wang, L., Acta Biomater., 2010, vol. 6, no. 50, pp. 1743–1748.CrossRefGoogle Scholar
  25. 25.
    Saremi, M. and Motaghi, G.B., Iran. J. Mater. Sci Eng., 2006, vol. 3, no. 3, pp. 1–5.Google Scholar
  26. 26.
    Song, Y., Shan, D., and Han, E., Mater. Lett., 2008, vol. 62, pp. 3276–3279.CrossRefGoogle Scholar
  27. 27.
    Li, W., Guan, S., Chen, J., et al., Mater. Charact., 2011, vol. 62, no. 12, pp. 1158–1165.CrossRefGoogle Scholar
  28. 28.
    Zhang, C.-Y., Zeng, R.-C., Liu, C.-L., and Gao, J.-C., Surf. Coat. Technol., 2010, vol. 204, nos. 21–22, pp. 3636–3640.Google Scholar
  29. 29.
    Meng, E., Guan, S., Wang, H., et al., Appl. Surf. Sci., 2011, vol. 257, no. 11, pp. 4811–4816.CrossRefGoogle Scholar
  30. 30.
    Kokubo, T. and Takadama, H., Biomaterials., 2006, vol. 27, pp. 2907–2915.CrossRefGoogle Scholar
  31. 31.
    Zhuang, H., Han, Y., and Feng, A., Mater. Sci. Eng., C., 2008, vol. 28, pp. 1462–1466.CrossRefGoogle Scholar
  32. 32.
    Kannan, M.B. and Raman, R., Biomaterials., 2008, vol. 29, no. 15, pp. 2306–2314.CrossRefGoogle Scholar

Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  1. 1.Department of Materials Engineering, Karaj BranchIslamic Azad UniversityKarajIran

Personalised recommendations