Fabrication of Cerium Oxide Nanoparticles by Solution Combustion Synthesis and Their Cytotoxicity Evaluation
- 14 Downloads
The diverse abilities such as the antioxidant effect of cerium oxide nanoparticles (CeO2-NPs) have encouraged researchers to pursue CeO2-NPs as a therapeutic agent to treat a number of diseases, including cancer and diabetes. The synthesis method of CeO2-NPs affected on its abilities. In this study, nanosize ceria powders were synthesized by combustion of aqueous containing corresponding cerium nitrate, ammonium nitrate, and glycine redox mixtures. Solution combustion synthesis is a fast and cost-efficient process with high purity product. The crystallite structures were characterized by various methods, including X-ray diffraction technique, high-resolution scanning electron microscopy, transmission electron microscopy, and UV–vis spectroscopy technique. The combustion was flaming and yields voluminous oxides with nano size (20–30 nm). In addition, no diffraction patterns that are characteristic of impurities were observed, indicating the purity of the CeO2-NPs. In vitro cytotoxicity studies on L929 cells, a non-toxic effect in all concentration (up to 1000 μg/mL) was indicated and it can be believed that this nanoparticle will have viable applications in different medical fields.
KeywordsCeO2 nanoparticle solution combustion synthesis cytotoxicity
Unable to display preview. Download preview PDF.
- 9.Pešic, M., Podolski-Renić, A., Stojković, S., Matović, B., Zmejkoski, D., Kojić, V., Bogdanović, G., Pavićević, A., Mojović, M., and Savić, A., Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity, Chem.-Biol. Interact., 2015, vol. 232, pp. 85–93.CrossRefGoogle Scholar
- 17.Bakkiyaraj, R., Bharath, G., Ramsait, K.H., Abdel-Wahab, A., Alsharaeh, E.H., Chen, S.-M., and Balakrishnan, M., Solution combustion synthesis and physico-chemical properties of ultrafine CeO2 nanoparticles and their photocatalytic activity, RSC Adv., 2016, vol. 6, pp. 51238–51245.CrossRefGoogle Scholar
- 20.Ravishankar, T.N., Ramakrishnappa, T., Nagaraju, G., and Rajanaika, H., Synthesis and Characterization of CeO2 nanoparticles via solution combustion method for photocatalytic and antibacterial activity studies, Chem.Open, 2015, vol. 4, pp. 146–154.Google Scholar
- 23.Demokritou, P., Gass, S., Pyrgiotakis, G., Cohen, J.M., Goldsmith, W., McKinney, W., Frazer, D., Ma, J., Schwegler-Berry, D., Brain, J., and Castranova, V., An in vivo and in vitro toxicological characterization of realistic nanoscale CeO2 inhalation exposures, Nanotoxicology, 2013, vol. 7, pp. 1338–1350.CrossRefGoogle Scholar
- 24.Karakoti, A.S., Munusamy, P., Hostetler, K., Kodali, V., Kuchibhatla, S., Orr, G., Pounds, J.G., Teeguarden, J.G., Thrall, B.D., and Baer, D.R., Preparation and characterization challenges to understanding environmental and biological impacts of nanoparticles, Surf. Interface Anal.: SIA, 2012, vol. 44, pp. 882–889.CrossRefGoogle Scholar
- 32.Pelletier, D.A., Suresh, A.K., Holton, G.A., McKeown, C.K., Wang, W., Gu, B., Mortensen, N.P., Allison, D.P., Joy, D.C., Allison, M.R., Brown, S.D., Phelps, T.J., and Doktycz, M.J., Effects of engineered cerium oxide nanoparticles on bacterial growth and viability, Appl. Environ. Microbiol., 2010, vol. 76, pp. 7981–7989.CrossRefGoogle Scholar