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A Look at Phage Therapy One Hundred Years After the Bacteriophages Discovery

  • T. S. Ilyina
  • E. R. Tolordava
  • Yu. M. RomanovaEmail author
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Abstract

This overview discusses the literature data on the use of bacteriophages in the treatment of both acute and chronic infectious diseases caused by antibiotic-resistant pathogens. Traditionally, phage therapy is based on the use of naturally occurring phages for infection and lysis of bacteria at the site of infection. It has fundamental advantages over antibiotic therapy. At the same time, it has some disadvantages. Currently, the application of biotechnological methods, such as the development of the recombinant bacteriophages, makes it possible to eliminate the shortcomings of antimicrobial phage therapy and to expand its opportunities due to the use of lytic proteins of phages and their modified derivatives.

Keywords:

bacteriophages phage therapy lytic proteins of phages antibiotic and phage resistance an alternative to antibiotics 

Notes

FUNDING

This study had no specific financial support.

COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any studies involving animals or human beings performed by any of the authors.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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Copyright information

© Allerton Press, Inc. 2019

Authors and Affiliations

  • T. S. Ilyina
    • 1
  • E. R. Tolordava
    • 1
  • Yu. M. Romanova
    • 1
    • 2
    Email author
  1. 1.Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian FederationMoscowRussia
  2. 2.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)MoscowRussia

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