Cytology and Genetics

, Volume 52, Issue 2, pp 132–138 | Cite as

Analysis of Single Nucleotide Polymorphisms G919A and A2039G of Gene FSHR in Infertile Men

  • I. S. Zhylkova
  • N. N. Sotnik
  • O. V. Yegunkova
  • O. M. Feskov
  • O. M. Fedota
Article
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Abstract

The polymorphic variants G919A and A2039G of the FSHR gene in men with azoospermia were investigated. In the nonobstructive form of azoospermia, the frequency of homozygotes GGAA, GGGG, and AAAA was 1.8–3.2 times higher than theoretically expected. In men with nonobstructive azoospermia, the highest level of follicle stimulating hormone (FSH) in serum was observed in homozygotes for the polymorphic variant G919A of gene FSHR; heterozygotes were characterized by intermediate values; wild-type homozygotes showed a low level, rs = 0.49. The FSH level in some patients with the nonobstructive form was at the upper limit or higher compared with the normal values, 19.07–33.42 mIU/mL, and the FSH level was in the normal range in the obstructive form. For obstructive azoospermia, the actual frequency of heterozygotes GGGG, GAAG, and AAAA was 2–5.1 times higher than expected; no homozygotes GGAA were found.

Keywords

azoospermia follicle-stimulating hormone G919A (Ala307Thr) and A2039G (Asn680Ser) FSHR gene 
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Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  • I. S. Zhylkova
    • 1
    • 2
  • N. N. Sotnik
    • 1
  • O. V. Yegunkova
    • 1
  • O. M. Feskov
    • 1
  • O. M. Fedota
    • 2
  1. 1.Feskov Center of Human ReproductionKharkivUkraine
  2. 2.Karazin Kharkiv National UniversityKharkivUkraine

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