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Synthesis of Amphiphilic Peptidomimetics Based on the Aliphatic Derivatives of Natural Amino Acids

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Abstract—The paper describes the production of a number of lipoamino acid derivatives based on L-serine, L-ornithine, and L-lysine with potential antibacterial activity. The designed synthesis schemes are distinguished by the simplicity and versatility of the approach used. This allows us to use them to obtain a series of samples in preparative quantities required to perform the subsequent physico-chemical and biochemical studies.

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Funding

The work was supported by the Russian Foundation for Basic Research (grant no. 17-04-01141).

Author information

Correspondence to Z. G. Denieva.

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The authors declare that they have no conflict of interest.

Additional information

Translated by E. Martynova

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Denieva, Z.G., Romanova, N.A., Bodrova, T.G. et al. Synthesis of Amphiphilic Peptidomimetics Based on the Aliphatic Derivatives of Natural Amino Acids. Moscow Univ. Chem. Bull. 74, 300–305 (2019). https://doi.org/10.3103/S0027131419060087

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Keywords:

  • antibacterial activity
  • lipoamino acids
  • aliphatic L-serine derivatives
  • L-lysine
  • L-ornithine
  • cationic amphiphiles