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Moscow University Chemistry Bulletin

, Volume 74, Issue 5, pp 236–240 | Cite as

Synthesis and Antimicrobial Activity of N-(Indolyl)trifluoroacetamides

  • I. S. Stepanenko
  • S. A. YamashkinEmail author
  • A. I. Kot’kin
  • M. A. Yurovskaya
Article
  • 8 Downloads

Abstract

A method for the synthesis of the corresponding trifluoroacetamides based on 2,3-dimethyl-, 1,2,3-trimethyl-7-aminoindoles and ethyl ester of trifluoroacetic acid is developed. The compounds obtained are screened for antimicrobial activity using the standard strains of the Staphylococcus aureus 29213, Escherichia coli 25922, Pseudomonas aeruginosa 27853, Streptococcus pyogenes 1238, and Klebsiella pneumonia 9172; and the antimicrobial activity comparable to dioksidin, a widely used antimicrobial drug, is demonstrated.

Keywords:

The reaction of heteroaromatic amines with ethyl ether of trifluoroacetic acid the synthesis of N‑(indolyl)-2,2,2-trifluoroacetamides antimicrobial activity of N-(indolyl) trifluoroacetamides 

Notes

COMPLIANCE WITH ETHICAL STANDARDS

This article does not contain any research using animals as objects.

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest.

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Copyright information

© Allerton Press, Inc. 2019

Authors and Affiliations

  • I. S. Stepanenko
    • 1
  • S. A. Yamashkin
    • 2
    Email author
  • A. I. Kot’kin
    • 2
  • M. A. Yurovskaya
    • 3
  1. 1.Ogarev Mordovia State UniversitySaranskRussia
  2. 2.Evseviev Mordovian State Pedagogical InstituteSaranskRussia
  3. 3.Department of Organic Chemistry, Moscow State UniversityMoscowRussia

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